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A 750-MHz Electronically Tunable Resonator Using Microstrip Line Couplers for Electron Paramagnetic Resonance Imaging of a Mouse Tumor-Bearing Leg

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/70435

Title: A 750-MHz Electronically Tunable Resonator Using Microstrip Line Couplers for Electron Paramagnetic Resonance Imaging of a Mouse Tumor-Bearing Leg
Authors: Amida, Tatsuya Browse this author
Nakaoka, Ririko Browse this author
Komarov, Denis A. Browse this author
Yamamoto, Kumiko Browse this author
Inanami, Osamu Browse this author →KAKEN DB
Matsumoto, Shingo Browse this author
Hirata, Hiroshi Browse this author →KAKEN DB
Keywords: Coils
couplers
electromagnetic waves
electron paramagnetic resonance
magnetic resonance imaging
radiofrequency
Issue Date: May-2018
Publisher: IEEE (Institute of Electrical and Electronics Engineers)
Journal Title: IEEE transactions on biomedical engineering
Volume: 65
Issue: 5
Start Page: 1124
End Page: 1132
Publisher DOI: 10.1109/TBME.2017.2743232
Abstract: Objective: The purpose of this work was to develop an electronically tunable resonator operating at 750 MHz for continuous-wave electron paramagnetic resonance (CW-EPR) imaging of a mouse tumor-bearing leg. Methods: The resonator had a multi-coil parallel-gap structure with a sample space of 16 mm in diameter and 20 mm in length. Microstrip line couplers were used in conjunction with varactor diodes to enable resonance frequency adjustment and to reduce the nonlinear effects of the varactor diodes. The resonator was modeled by the finite-element method and a microwave circuit simulation was performed to clarify its radiofrequency characteristics. Results: A tunable resonator was evaluated in terms of its resonance frequency, tunable frequency band, and conversion efficiency of the RF magnetic field. The developed resonator provided a tunable frequency band of 4 MHz at a central frequency of 747 MHz and a conversion efficiency of 34 mu T/W-1/2. To demonstrate the application of this tunable resonator to EPR imaging, three-dimensional EPR images of a sample solution and a mouse tumor-bearing leg were obtained. Conclusion: The developed tunable resonator satisfied our initial requirements for in vivo EPR imaging and may be able to be further improved using the present finite-element and circuit models if any problems arise during future practical applications. Significance: This work may help to promote EPR imaging of tumor-bearing mice in cancer-related studies.
Rights: © 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Type: article (author version)
URI: http://hdl.handle.net/2115/70435
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 拓

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