| Title: | Bi-ventricular interplay in patients with systemic sclerosis-associated pulmonary arterial hypertension : Detection by cardiac magnetic resonance |
| Authors: | Noguchi, Atsushi Browse this author |
| Kato, Masaru Browse this author →KAKEN DB |
| Kono, Michihito Browse this author |
| Ohmura, Kazumasa Browse this author |
| Ohira, Hiroshi Browse this author |
| Tsujino, Ichizo Browse this author →KAKEN DB |
| Oyama-Manabe, Noriko Browse this author →KAKEN DB |
| Oku, Kenji Browse this author |
| Bohgaki, Toshiyuki Browse this author |
| Horita, Tetsuya Browse this author →KAKEN DB |
| Yasuda, Shinsuke Browse this author →KAKEN DB |
| Nishimura, Masaharu Browse this author →KAKEN DB |
| Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | Cardiac magnetic resonance |
| Connective tissue diseases |
| Prognosis |
| Pulmonary arterial hypertension |
| Systemic sclerosis |
| Issue Date: | 2017 |
| Publisher: | Taylor & Francis |
| Journal Title: | Modern rheumatology |
| Volume: | 27 |
| Issue: | 3 |
| Start Page: | 481 |
| End Page: | 488 |
| Publisher DOI: | 10.1080/14397595.2016.1218597 |
| PMID: | 27535805 |
| Abstract: | Objectives: Pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc) has a poor prognosis compared to PAH associated with other connective tissue diseases (CTD). The objective of this study was to examine the difference in hemodynamic state between SSc-PAH and other CTD-PAH by performing cardiac magnetic resonance (CMR) imaging.Methods: A single center retrospective analysis was conducted comprising 40 consecutive CTD patients who underwent right heart catheterization and CMR at the same period from January 2010 to October 2015. Results: Thirty-two patients had pre-capillary pulmonary hypertension. Of these, 15 had SSc and 17 had other CTD. CMR measurements, particularly the ratio of right to left end-diastolic volume (RVEDV/LVEDV), correlated well with mean pulmonary arterial pressure (mPAP). Conversely, RVEDV/LVEDV and mPAP correlated differently in SSc and non-SSc patients. In SSc patients, the ratio of RVEDV/LVEDV to mPAP was significantly higher compared to non-SSc patients. In the follow-up study, 2 SSc patients exhibited increased RVEDV/LVEDV in spite of decreased mPAP following treatment. Kaplan-Meier analysis revealed poor prognosis of patients with increased RVEDV/LVEDV following treatment. Conclusions: Our data indicated that altered bi-ventricular interplay detected at CMR may represent SSc-related cardiac involvement and reflect poor prognosis of SSc-PAH. |
| Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in Modern Rheumatology in 2017, available online: http://www.tandfonline.com/10.1080/14397595.2016.1218597 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/70644 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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