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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Refining prognosis in patients with hepatocellular carcinoma through incorporation of metabolic imaging biomarkers
| Title: | Refining prognosis in patients with hepatocellular carcinoma through incorporation of metabolic imaging biomarkers |
| Authors: | Takeuchi, Satoshi Browse this author | | Rohren, Eric M. Browse this author | | Abdel-Wahab, Reham Browse this author | | Xiao, Lianchun Browse this author | | Morris, Jeffrey S. Browse this author | | Macapinlac, Homer A. Browse this author | | Hassan, Manal M. Browse this author | | Kaseb, Ahmed O. Browse this author |
| Keywords: | FDG PET/CT | | Hepatocellular carcinoma | | CLIP scoring system | | BCLC staging system |
| Issue Date: | Jun-2017 |
| Publisher: | Springer |
| Journal Title: | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 44 |
| Issue: | 6 |
| Start Page: | 969 |
| End Page: | 978 |
| Publisher DOI: | 10.1007/s00259-016-3583-2 |
| Abstract: | Purpose: 18F-fluorodeoxyglucose positron emission tomopraphy/computed tomography (FDGPET/CT) has been proven to be useful for imaging many types of cancer; however, its role is not well defined in hepatocellular carcinoma (HCC). We assessed the prognostic value of metabolic imaging biomarkers as established by baseline pretreatment FDG PET/CT in patients with HCC. Methods: We retrospectively analyzed the records of patients with HCC who underwent FDG PET/CT before initial treatment from May 2013 through May 2014. Four PET/CT parameters were measured: maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), metabolic tumor volume (MTV), and tumor-to-normal-liver SUV ratio (TNR). Optimal cut-off values for the PET/CT parameters to stratify patients in terms of overall survival (OS) were determined. Multivariate analysis was performed to determine whether the PET/CT parameters could add to the prognostic value of the Cancer of the Liver Italian Program (CLIP) scoring system and the Barcelona-Clinic Liver Cancer (BCLC) staging system. Results: The analysis included 56 patients. Univariate analysis of the association between OS and continuous variables, including the PET/CT parameters SUVmax, TLG, tumor size, total bilirubin level, and alkaline phosphatase level were significant predictors of OS. SUVmax ≥ 11.7, TLG ≥ 1,341, MTV ≥ 230 mL, and TNR ≥ 4.8 were identified as cut-off values. Multivariate analysis revealed that SUVmax ≥ 11.7 and TNR ≥ 4.8 were independent factors predicting a poor prognosis in both the CLIP scoring system and the BCLC staging system, as was TLG in the BCLC staging system. Conclusion: Pretreatment FDG PET/CT in patients with HCC can add to the prognostic value of standard clinical measures. Incorporation of imaging biomarkers derived from FDG PET/CT into HCC staging systems should be considered. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/70645 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 竹内 啓
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