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Stereoselective Synthesis of Tetrasubstituted Alkenes via a Cp*Co-III-Catalyzed C-H Alkenylation/Directing Group Migration Sequence
Title: | Stereoselective Synthesis of Tetrasubstituted Alkenes via a Cp*Co-III-Catalyzed C-H Alkenylation/Directing Group Migration Sequence |
Authors: | Ikemoto, Hideya Browse this author | Tanaka, Ryo Browse this author | Sakata, Ken Browse this author | Kanai, Motomu Browse this author | Yoshino, Tatsuhiko Browse this author →KAKEN DB | Matsunaga, Shigeki Browse this author →KAKEN DB |
Keywords: | C-H activation | cobalt | first row transition metals | homogeneous catalysis | indoles |
Issue Date: | 12-Jun-2017 |
Publisher: | Wiley-Blackwell |
Journal Title: | Angewandte chemie-international edition |
Volume: | 56 |
Issue: | 25 |
Start Page: | 7156 |
End Page: | 7160 |
Publisher DOI: | 10.1002/anie.201703193 |
PMID: | 28508443 |
Abstract: | A highly atom economical and stereoselective synthesis of tetrasubstituted alpha,beta-unsaturated amides was achieved by a Cp*Co-III-catalyzed C-H alkenylation/directing group migration sequence. A carbamoyl directing group, which is typically removed after C-H functionalization, worked as an internal acylating agent and migrated onto the alkene moiety of the product. The directing group migration was realized with the Cp*Co-III catalyst, while a related Cp*Rh-III catalyst did not promote the migration process. The product was further converted into two types of tricyclic compounds, one of which had fluorescent properties. |
Rights: | This is the peer reviewed version of the following article: Angewandte chemie-international edition,56(25),7156-7160,2017 which has been published in final form at doi.org/10.1002/anie.201703193. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/70699 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 吉野 達彦
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