|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Engineering / Faculty of Engineering >
Peer-reviewed Journal Articles, etc >
Asymmetric hydrogenation of ketones : Tactics to achieve high reactivity, enantioselectivity, and wide scope
| Title: | Asymmetric hydrogenation of ketones : Tactics to achieve high reactivity, enantioselectivity, and wide scope |
| Authors: | OHKUMA, Takeshi Browse this author →KAKEN DB |
| Keywords: | asymmetric hydrogenation | | chiral alcohols | | enantioselectivity | | Ir catalysts | | ketones | | Ru catalysts |
| Issue Date: | 2010 |
| Publisher: | Japan Academy |
| Journal Title: | Proceedings of the Japan Academy, Series B |
| Volume: | 86 |
| Issue: | 3 |
| Start Page: | 202 |
| End Page: | 219 |
| Publisher DOI: | 10.2183/pjab.86.202 |
| Abstract: | Ru complexes with chiral diphosphines and amine-based ligands achieve high catalytic activity and enantioselectivity for the hydrogenation of ketones under neutral to slightly basic conditions. The chiral environment is controllable by changing the combination of these two ligands. A concerted six-membered transition state is proposed to be the origin of the high reactivity. The η6-arene/TsDPEN–Ru and MsDPEN–Cp*Ir catalysts effect the asymmetric reaction under slightly acidic conditions. A variety of chiral secondary alcohols are obtained in high enantiomeric excess. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70735 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 大熊 毅
|
