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Assessing the uncertainty in a normal tissue complication probability difference (ΔNTCP) : radiation-induced liver disease (RILD) in liver tumour patients treated with proton vs X-ray therapy
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| Title: | Assessing the uncertainty in a normal tissue complication probability difference (ΔNTCP) : radiation-induced liver disease (RILD) in liver tumour patients treated with proton vs X-ray therapy |
| Authors: | Kobashi, Keiji Browse this author | | Prayongrat, Anussara Browse this author | | Kimoto, Takuya Browse this author | | Toramatsu, Chie Browse this author | | Dekura, Yasuhiro Browse this author | | Katoh, Norio Browse this author →KAKEN DB | | Shimizu, Shinichi Browse this author →KAKEN DB | | Ito, Yoichi M. Browse this author →KAKEN DB | | Shirato, Hiroki Browse this author →KAKEN DB |
| Keywords: | normal tissue complication probability | | uncertainty | | proton therapy | | radiation-induced liver disease | | liver tumour |
| Issue Date: | 1-Mar-2018 |
| Publisher: | Oxford University Press |
| Journal Title: | Journal of Radiation Research |
| Volume: | 59 |
| Issue: | suppl_1 |
| Start Page: | i50 |
| End Page: | i57 |
| Publisher DOI: | 10.1093/jrr/rry018 |
| Abstract: | Modern radiotherapy technologies such as proton beam therapy (PBT) permit dose escalation to the tumour and minimize unnecessary doses to normal tissues. To achieve appropriate patient selection for PBT, a normal tissue complication probability (NTCP) model can be applied to estimate the risk of treatment-related toxicity relative to X-ray therapy (XRT). A methodology for estimating the difference in NTCP (ΔNTCP), including its uncertainty as a function of dose to normal tissue, is described in this study using the Delta method, a statistical method for evaluating the variance of functions, considering the variance-covariance matrix. We used a virtual individual patient dataset of radiation-induced liver disease (RILD) in liver tumour patients who were treated with XRT as a study model. As an alternative option for individual patient data, dose-bin data, which consists of the number of patients who developed toxicity in each dose level/bin and the total number of patients in that dose level/bin, are useful for multi-institutional data sharing. It provides comparable accuracy with individual patient data when using the Delta method. With reliable NTCP models, the ΔNTCP with uncertainty might potentially guide the use of PBT; however, clinical validation and a cost-effectiveness study are needed to determine the appropriate ΔNTCP threshold. |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70874 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小橋 啓司
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