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Effect of repeated forearm muscle cooling on the adaptation of skeletal muscle metabolism in humans
| Title: | Effect of repeated forearm muscle cooling on the adaptation of skeletal muscle metabolism in humans |
| Authors: | Wakabayashi, Hitoshi Browse this author | | Nishimura, Takayuki Browse this author | | Wijayanto, Titis Browse this author | | Watanuki, Shigeki Browse this author | | Tochihara, Yutaka Browse this author |
| Keywords: | Hypothermic skeletal muscle | | Tissue oxygenation | | Non-shivering thermogenesis | | Local cold exposure | | Cold adaptation |
| Issue Date: | Jul-2017 |
| Publisher: | Springer |
| Journal Title: | International journal of biometeorology |
| Volume: | 61 |
| Issue: | 7 |
| Start Page: | 1261 |
| End Page: | 1267 |
| Publisher DOI: | 10.1007/s00484-016-1303-z |
| PMID: | 28083707 |
| Abstract: | This study aimed to investigate the effect of repeated cooling of forearm muscle on adaptation in skeletal muscle metabolism. It is hypothesized that repeated decreases of muscle temperature would increase the oxygen consumption in hypothermic skeletal muscle. Sixteen healthy males participated in this study. Their right forearm muscles were locally cooled to 25 A degrees C by cooling pads attached to the skin. This local cooling was repeated eight times on separate days for eight participants (experimental group), whereas eight controls received no cold exposure. To evaluate adaptation in skeletal muscle metabolism, a local cooling test was conducted before and after the repeated cooling period. Change in oxy-hemoglobin content in the flexor digitorum at rest and during a 25-s isometric handgrip (10% maximal voluntary construction) was measured using near-infrared spectroscopy at every 2 A degrees C reduction in forearm muscle temperature. The arterial blood flow was occluded for 15 s by upper arm cuff inflation at rest and during the isometric handgrip. The oxygen consumption in the flexor digitorum muscle was evaluated by a slope of the oxy-hemoglobin change during the arterial occlusion. In the experimental group, resting oxygen consumption in skeletal muscle did not show any difference between pre- and post-intervention, whereas muscle oxygen consumption during the isometric handgrip was significantly higher in post-intervention than in pre-test from thermoneutral baseline to 31 A degrees C muscle temperature (P < 0.05). This result indicated that repeated local muscle cooling might facilitate oxidative metabolism in the skeletal muscle. In summary, skeletal muscle metabolism during submaximal isometric handgrip was facilitated after repeated local muscle cooling. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/70879 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 若林 斉
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