Nickel-catalyzed hydrocarboxylation of ynamides with CO2 and H2O : observation of unexpected regioselectivity


Hokkaido University \| Library \| HUSCAP	Advanced Search		言語

	Home
	About HUSCAP
	Open Access Policy

	Browse by Author

Browse
	Communities & Collections

	Scholarly Journals
	Theses
	Doctoral Dissertations Listed by Graduate Schools
	Conference Procs.
	Events

	HUSCAP Senior (in Japanese)

	Societies

	Downloads (country)

For university staff
	How to post your papers to HUSCAP
	Publication of theses
	Helpline about theses publication

Open Archives Compliant

You can search our collection also at:
	Google
	Google Scholar
	CiNii
	IRDB
	OAIster
	NDLTD

Files in This Item:

WoS_80413_doi.pdf

303.25 kB

PDF

Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/70974

Title:	Nickel-catalyzed hydrocarboxylation of ynamides with CO2 and H2O : observation of unexpected regioselectivity
Authors:	Doi, Ryohei Browse this author
	Abdullah, Iman Browse this author
	Taniguchi, Takahisa Browse this author
	Saito, Nozomi Browse this author
	Sato, Yoshihiro Browse this author →KAKEN DB
Issue Date:	14-Jul-2017
Publisher:	Royal Society of Chemistry
Journal Title:	Chemical communications
Volume:	53
Issue:	55
Start Page:	7720
End Page:	7723
Publisher DOI:	10.1039/c7cc03127k
PMID:	28569298
Abstract:	We describe the nickel-catalyzed hydrocarboxylation of ynamides with CO2 and H2O to afford a variety of alpha-amino-alpha, beta-unsaturated esters with high regioselectivities. The selective alpha-carboxylation of ynamides with this catalytic protocol is unexpected in view of the electronic bias of ynamides and is in sharp contrast to our previous study in which a stoichiometric amount of Ni(0) was used to form a beta-carboxylated product exclusively. We revealed that this unexpected C-C bond formation was induced by the combination of Zn and MgBr2.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/70974
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 土井良平

OAI-PMH ( junii2 , jpcoar_1.0 )

- Hokkaido University