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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing
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| Title: | Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing |
| Authors: | Kunimatsu, Jun Browse this author →KAKEN DB | | Suzuki, Tomoki W Browse this author | | Ohmae, Shogo Browse this author | | Tanaka, Masaki Browse this author →KAKEN DB |
| Issue Date: | 2-Jul-2018 |
| Publisher: | eLife Sciences Publications |
| Journal Title: | Elife |
| Volume: | 7 |
| Start Page: | e35676 |
| Publisher DOI: | 10.7554/eLife.35676 |
| Abstract: | The ability to flexibly adjust movement timing is important for everyday life. Although the basal ganglia and cerebellum have been implicated in monitoring of supra-and sub-second intervals, respectively, the underlying neuronal mechanism remains unclear. Here, we show that in monkeys trained to generate a self-initiated saccade at instructed timing following a visual cue, neurons in the caudate nucleus kept track of passage of time throughout the delay period, while those in the cerebellar dentate nucleus were recruited only during the last part of the delay period. Conversely, neuronal correlates of trial-by-trial variation of self-timing emerged earlier in the cerebellum than the striatum. Local inactivation of respective recording sites confirmed the difference in their relative contributions to supra-and sub-second intervals. These results suggest that the basal ganglia may measure elapsed time relative to the intended interval, while the cerebellum might be responsible for the fine adjustment of self-timing. |
| Rights: | https://creativecommons.org/publicdomain/zero/1.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/71497 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 田中 真樹
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