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Therapeutic application of human leukocyte antigen-G1 improves atopic dermatitis-like skin lesions in mice

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Title: Therapeutic application of human leukocyte antigen-G1 improves atopic dermatitis-like skin lesions in mice
Authors: Maeda, Naoyoshi Browse this author →KAKEN DB
Yamada, Chisato Browse this author
Takahashi, Ami Browse this author
Kuroki, Kimiko Browse this author →KAKEN DB
Maenaka, Katsumi Browse this author →KAKEN DB
Keywords: Atopic dermatitis
Dermatophagoides farinae
NC/Nga mice
Issue Date: Sep-2017
Publisher: Elsevier
Journal Title: International immunopharmacology
Volume: 50
Start Page: 202
End Page: 207
Publisher DOI: 10.1016/j.intimp.2017.06.026
PMID: 28675838
Abstract: Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that plays critical roles in immune response and in triggering inhibitory signaling to immune cells such as T cells, natural killer cells, and antigen presenting cells. Thus, the application of HLA-G can be considered for treating immune response-related inflammatory disorders. We have previously reported that treatment with HLA-Gl and HLA-G2 ameliorates the joint swelling associated with collagen-induced arthritis of DBA/1 mice, an animal model for rheumatoid arthritis. In this study, we further investigated the effects of HLA-G1 on atopic dermatitis (AD), the most common inflammatory skin disorder. AD-like lesions were induced with the extract of the house dust mite Dermatophagoides farinae in NC/Nga mice. Continuous administration of HLA-G1 ameliorated the AD-like skin lesions in the mice. Furthermore, production of immunoglobulin E, interleukin (IL)-13, and IL-17A was significantly reduced in HLA-Gl-treated mice, suggesting a Th2/Th17-mediated immune-inhibitory function of HLA-G1 in vivo. Our studies shed light on novel therapeutic strategies with recombinant HLA-G proteins for immune reaction-mediated chronic inflammatory disorders.
Rights: ©2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 前田 直良

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