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Therapeutic application of human leukocyte antigen-G1 improves atopic dermatitis-like skin lesions in mice
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| Title: | Therapeutic application of human leukocyte antigen-G1 improves atopic dermatitis-like skin lesions in mice |
| Authors: | Maeda, Naoyoshi Browse this author →KAKEN DB | | Yamada, Chisato Browse this author | | Takahashi, Ami Browse this author | | Kuroki, Kimiko Browse this author →KAKEN DB | | Maenaka, Katsumi Browse this author →KAKEN DB |
| Keywords: | Atopic dermatitis | | Dermatophagoides farinae | | HLA-G1 | | NC/Nga mice |
| Issue Date: | Sep-2017 |
| Publisher: | Elsevier |
| Journal Title: | International immunopharmacology |
| Volume: | 50 |
| Start Page: | 202 |
| End Page: | 207 |
| Publisher DOI: | 10.1016/j.intimp.2017.06.026 |
| PMID: | 28675838 |
| Abstract: | Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that plays critical roles in immune response and in triggering inhibitory signaling to immune cells such as T cells, natural killer cells, and antigen presenting cells. Thus, the application of HLA-G can be considered for treating immune response-related inflammatory disorders. We have previously reported that treatment with HLA-Gl and HLA-G2 ameliorates the joint swelling associated with collagen-induced arthritis of DBA/1 mice, an animal model for rheumatoid arthritis. In this study, we further investigated the effects of HLA-G1 on atopic dermatitis (AD), the most common inflammatory skin disorder. AD-like lesions were induced with the extract of the house dust mite Dermatophagoides farinae in NC/Nga mice. Continuous administration of HLA-G1 ameliorated the AD-like skin lesions in the mice. Furthermore, production of immunoglobulin E, interleukin (IL)-13, and IL-17A was significantly reduced in HLA-Gl-treated mice, suggesting a Th2/Th17-mediated immune-inhibitory function of HLA-G1 in vivo. Our studies shed light on novel therapeutic strategies with recombinant HLA-G proteins for immune reaction-mediated chronic inflammatory disorders. |
| Rights: | ©2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/71552 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 前田 直良
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