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Confocal Microscopic Evaluation of Mixing Performance for Three-Dimensional Microfluidic Mixer

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Title: Confocal Microscopic Evaluation of Mixing Performance for Three-Dimensional Microfluidic Mixer
Authors: YASUI, Takao Browse this author
OMOTO, Yusuke Browse this author
OSATO, Keiko Browse this author
KAJI, Noritada Browse this author
SUZUKI, Norikazu Browse this author
NAITO, Toyohiro Browse this author
OKAMOTO, Yukihiro Browse this author
TOKESHI, Manabu Browse this author →KAKEN DB
SHAMOTO, Eiji Browse this author
BABA, Yoshinobu Browse this author
Keywords: confocal microscopic method
Issue Date: 10-Jan-2012
Publisher: 日本分析化学会
Journal Title: Analytical Sciences
Volume: 28
Issue: 1
Start Page: 57
End Page: 59
Publisher DOI: 10.2116/analsci.28.57
Abstract: We developed a confocal microscopic method for a quantitative evaluation of the mixing performance of a three-dimensional microfluidic mixer. We fabricated a microfluidic baker’s transformation (MBT) mixer as a three-dimensional passive-type mixer for the efficient mixing of solutions. Although the MBT mixer is one type of ideal mixers, it is hard to evaluate its mixing performance, since the MBT mixer is based on several cycles of complicated three-dimensional microchannel structures. We applied the method developed here to evaluate the mixing of water and a fluorescein isothiocyanate (FITC; diffusion coefficient, 4.9 × 10−10 m2 s−1) solution by the MBT mixer. This method enables us to capture vertical section images for the fluid distributions of FITC and water at different three-dimensional microchannel structures of the MBT device. These images are in good agreement with those of mixing images based on numerical simulations. The mixing ratio could be calculated by the fluorescence intensity at each pixel of the vertical section image; complete mixing is recognized by a mixing ratio of more than 90%. The mixing ratios are measured at different cycles of the MBT mixer by changing the flow rate; the mixing performance is evaluated by comparisons with the mixing ratio of the straight microchannel without the MBT mixer.
Type: article
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 渡慶次 学

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