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Association between DNA methylation in cord blood and maternal smoking : The Hokkaido Study on Environment and Children's Health

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Title: Association between DNA methylation in cord blood and maternal smoking : The Hokkaido Study on Environment and Children's Health
Authors: Miyake, Kunio Browse this author
Kawaguchi, Akio Browse this author
Miura, Ryu Browse this author
Kobayashi, Sachiko Browse this author
Tran, Nguyen Quoc Vuong Browse this author
Kobayashi, Sumitaka Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Kubota, Takeo Browse this author
Yamagata, Zentaro Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Issue Date: 4-Apr-2018
Publisher: Nature Publishing Group
Journal Title: Scientific Reports
Volume: 8
Start Page: 5654
Publisher DOI: 10.1038/s41598-018-23772-x
Abstract: Maternal smoking is reported to cause adverse effects on the health of the unborn child, the underlying mechanism for which is thought to involve alterations in DNA methylation. We examined the effects of maternal smoking on DNA methylation in cord blood, in 247 mother-infant pairs in the Sapporo cohort of the Hokkaido Study, using the Infinium HumanMethylation 450K BeadChip. We first identified differentially methylated CpG sites with a false discovery rate (FDR) of <0.05 and the magnitude of DNA methylation changes (|β| >0.02) from the pairwise comparisons of never-smokers (Ne-S), sustained-smokers (Su-S), and stopped-smokers (St-S). Subsequently, secondary comparisons between St-S and Su-S revealed nine common sites that mapped to ACSM3, AHRR, CYP1A1, GFI1, SHANK2, TRIM36, and the intergenic region between ANKRD9 and RCOR1 in Ne-S vs. Su-S, and one common CpG site mapping to EVC2 in Ne-S vs. St-S. Further, we verified these CpG sites and examined neighbouring sites using bisulfite next-generation sequencing, except for AHRR cg21161138. These changes in DNA methylation implicate the effect of smoking cessation. Our findings add to the current knowledge of the association between DNA methylation and maternal smoking and suggest future studies for clarifying this relationship in disease development.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/71755
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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