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Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age : the Hokkaido Study on Environment and Children's Health

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Title: Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age : the Hokkaido Study on Environment and Children's Health
Authors: Minatoya, Machiko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Yamazaki, Keiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Tamura, Naomi Browse this author →KAKEN DB
Yamamoto, Jun Browse this author
Onoda, Yu Browse this author
Ogasawara, Kazuki Browse this author
Matsumura, Toru Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: SDQ
Bisphenol A
Phthalates
Prenatal exposure
Birth cohort
Behavioral problems
Issue Date: 7-Sep-2018
Publisher: Springer
Journal Title: Environmental Health and Preventive Medicine
Volume: 23
Start Page: 43
Publisher DOI: 10.1186/s12199-018-0732-1
Abstract: Background: Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age. Methods: The Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels in the first trimester maternal serum was determined by LC-MS/MS for 458 children. Variables used for adjustment were parental ages, maternal cotinine levels, family income during pregnancy, child sex, birth order, and age at SDQ completed. Results: The median concentrations of BPA, MnBP, MiBP, MEHP, and MECPP, primary and secondary metabolites of phthalates, were 0.062, 26.0, 7.0, 1.40, and 0.20 ng/ml, respectively. MECPP level was associated with increase conduct problem risk (OR = 2.78, 95% CI 1.36-5.68) overall and the association remained after child sex stratification, and odds ratios were increased with wider confidence interval (OR = 2.85, 95% CI 1.07-7.57 for boys, OR = 4.04, 95% CI 1.31-12.5 for girls, respectively). BPA, ∑DBPm (MnBP + MiBP), and ∑DEHPm (MEHP+MECPP) levels were not associated with any of the child behavioral problems. Conclusions: Our analyses found no significant association between BPA or summation of phthalate metabolite levels and any of the behavioral problems at 5 years of age but suggested possible association between MECPP levels and increased risk of conduct problems.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/71756
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 湊屋 街子

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