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Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/71967

Title: Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules
Authors: Menezes, Halley M. Browse this author
Islam, Md. Jahirul Browse this author
Takahashi, Masayuki Browse this author
Tamaoki, Nobuyuki Browse this author →KAKEN DB
Issue Date: 14-Nov-2017
Publisher: Royal Society of Chemistry
Journal Title: Organic & biomolecular chemistry
Volume: 15
Issue: 42
Start Page: 8894
End Page: 8903
Publisher DOI: 10.1039/c7ob01293d
PMID: 28902195
Abstract: We employed an azobenzene based non-nucleoside triphosphate, AzoTP, in a myosin-actin motile system and demonstrated its efficiency as an energy molecule to drive and photo-regulate the myosin-actin motile function at the macroscopic level along with an in vitro motility assay. The AzoTP in its trans state induced shortening of a glycerinated muscle fibre whilst a cis isomer had no significant effect. Direct photoirradiation of a cis-AzoTP infused muscle fibre induced shortening triggered by a locally photo-generated trans-AzoTP in the muscle fibre. Furthermore, we designed and synthesized three new derivatives of AzoTPs that served as substrates for myosin by driving and photo-regulating the myosin-actin motile function at the molecular as well as the macroscopic level with varied efficiencies.
Type: article (author version)
URI: http://hdl.handle.net/2115/71967
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉置 信之

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