Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

Menezes, Halley M.; Islam, Md. Jahirul; Takahashi, Masayuki; Tamaoki, Nobuyuki

doi:10.1039/c7ob01293d


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Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/71967

Title:	Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules
Authors:	Menezes, Halley M. Browse this author
	Islam, Md. Jahirul Browse this author
	Takahashi, Masayuki Browse this author
	Tamaoki, Nobuyuki Browse this author →KAKEN DB
Issue Date:	14-Nov-2017
Publisher:	Royal Society of Chemistry
Journal Title:	Organic & biomolecular chemistry
Volume:	15
Issue:	42
Start Page:	8894
End Page:	8903
Publisher DOI:	10.1039/c7ob01293d
PMID:	28902195
Abstract:	We employed an azobenzene based non-nucleoside triphosphate, AzoTP, in a myosin-actin motile system and demonstrated its efficiency as an energy molecule to drive and photo-regulate the myosin-actin motile function at the macroscopic level along with an in vitro motility assay. The AzoTP in its trans state induced shortening of a glycerinated muscle fibre whilst a cis isomer had no significant effect. Direct photoirradiation of a cis-AzoTP infused muscle fibre induced shortening triggered by a locally photo-generated trans-AzoTP in the muscle fibre. Furthermore, we designed and synthesized three new derivatives of AzoTPs that served as substrates for myosin by driving and photo-regulating the myosin-actin motile function at the molecular as well as the macroscopic level with varied efficiencies.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/71967
Appears in Collections:	電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉置信之

OAI-PMH ( junii2 , jpcoar_1.0 )

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