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JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise

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Title: JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
Authors: Tanaka, Yoshitaro Browse this author
Yasugi, Tetsuo Browse this author
Nagayama, Masaharu Browse this author →KAKEN DB
Sato, Makoto Browse this author
Ei, Shin-Ichiro Browse this author →KAKEN DB
Keywords: Cellular noise
Developmental neurogenesis
Neural progenitors
Issue Date: 20-Aug-2018
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 8
Start Page: 12484
Publisher DOI: 10.1038/s41598-018-30929-1
Abstract: Organismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo, and the mechanisms by which noise is filtered during development are largely unknown. To identify the noise-canceling mechanism, we used the fly visual system, in which the timing of differentiation of neural stem cells is spatio-temporally ordered. Our mathematical model predicts that JAK/STAT signaling contributes to noise canceling to guarantee the robust progression of the differentiation wave in silico. We further demonstrate that the suppression of JAK/STAT signaling causes stochastic and ectopic neural stem cell differentiation in vivo, suggesting an evolutionarily conserved function of JAK/STAT to regulate the robustness of stem cell differentiation.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 栄 伸一郎

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