Hokkaido University Collection of Scholarly and Academic Papers >
Center for Environmental and Health Sciences >
Peer-reviewed Journal Articles, etc >
Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants : The Hokkaido Study on Environment and Children's Health
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Title: | Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants : The Hokkaido Study on Environment and Children's Health |
Authors: | Minatoya, Machiko Browse this author →KAKEN DB | Nakajima, Sonomi Browse this author | Sasaki, Seiko Browse this author →KAKEN DB | Araki, Atsuko Browse this author →KAKEN DB | Miyashita, Chihiro Browse this author →KAKEN DB | Ikeno, Tamiko Browse this author →KAKEN DB | Nakajima, Tamie Browse this author | Goto, Yuko Browse this author | Kishi, Reiko Browse this author →KAKEN DB |
Keywords: | Di (2-ethylhexyl) phthalate | Thyroid hormone | Neurodevelopment | Prenatal Exposure |
Issue Date: | 15-Sep-2016 |
Publisher: | Elsevier |
Journal Title: | Science of The Total Environment |
Volume: | 565 |
Start Page: | 1037 |
End Page: | 1043 |
Publisher DOI: | 10.1016/j.scitotenv.2016.05.098 |
PMID: | 27261429 |
Abstract: | Di (2-ethylhexyl) phthalate (DEHP) is commonly used phthalates and concerns of adverse effects of prenatal DEHP exposure on neonatal thyroid hormone (TH) and neurodevelopment are increasing. However, there is no report regarding association between prenatal DEHP exposure and infant neurodevelopment including TH levels in Japanese population. Thus the aim of present study was to evaluate the associations between prenatal DEHP exposure and mental and psychomotor development of infants 6 and 18 months along with investigating influence on neonatal free thyroxine (FT4) and thyroid stimulating hormone (TSH) levels in the prospective birth cohort study. Maternal blood samples collected between 23-41 weeks of gestation was analyzed for mono (2-ethylhexyl) phthalate (MEHP), metabolite of DEHP levels. Neonatal FT4 and TSH were obtained from mass screening data. Infant neurodevelopment was assessed by Bayley Scale of Infant Development second edition at 6 and 18 month of age. For the final analysis, 328 participants were included. The median levels of maternal MEHP was 10.6 ng/ml, neonatal TSH and FT4 was 2.20 μU/ml and 2.03 ng/ml, respectively. We did not find any associations between prenatal DEHP exposure and neonatal TH levels or infant mental and psychomotor development at 6 and 18 month.
In this study, prenatal DEHP exposure did not show adverse effects on infant TH levels or mental and psychomotor development in early life stage. However, our previous study revealed negative effects of prenatal DEHP exposure on sex hormone levels, continuous investigation on neurodevelopment in later life in association with prenatal DEHP exposure is necessary. |
Rights: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/71999 |
Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 湊屋 街子
|