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Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice


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タイトル: Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice
著者: Deyama, Satoshi 著作を一覧する
Shimoda, Kento 著作を一覧する
Ikeda, Hiroyuki 著作を一覧する
Fukuda, Hayato 著作を一覧する
Shuto, Satoshi 著作を一覧する
Minami, Masabumi 著作を一覧する
キーワード: Antidepressant
omega-3 polyunsaturated fatty acid
発行日: 2018年 9月
出版者: Japanese Pharmacological Society
誌名: Journal of pharmacological sciences
巻: 138
号: 1
開始ページ: 86
終了ページ: 88
出版社 DOI: 10.1016/j.jphs.2018.09.006
PMID: 30293959
抄録: Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS (0.8 mg/kg, i.p.) significantly increased immobility time on the tail suspension test, and this depression-like behavior was dose-dependently attenuated by intracerebroventricular infusion of RvE3 (10 or 100 ng). No effects of LPS or intracerebroventricular infusion of RvE3 on locomotor activity were observed. These results indicate that RvE3, as well as RvE1 and RvE2, have antidepressant effects. (C) 2018 The Authors. Production and hosting by Elsevier B.V.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 南 雅文


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