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Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

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Title: Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice
Authors: Deyama, Satoshi Browse this author
Shimoda, Kento Browse this author
Ikeda, Hiroyuki Browse this author
Fukuda, Hayato Browse this author
Shuto, Satoshi Browse this author →KAKEN DB
Minami, Masabumi Browse this author →KAKEN DB
Keywords: Antidepressant
omega-3 polyunsaturated fatty acid
Issue Date: Sep-2018
Publisher: Japanese Pharmacological Society
Journal Title: Journal of pharmacological sciences
Volume: 138
Issue: 1
Start Page: 86
End Page: 88
Publisher DOI: 10.1016/j.jphs.2018.09.006
PMID: 30293959
Abstract: Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS (0.8 mg/kg, i.p.) significantly increased immobility time on the tail suspension test, and this depression-like behavior was dose-dependently attenuated by intracerebroventricular infusion of RvE3 (10 or 100 ng). No effects of LPS or intracerebroventricular infusion of RvE3 on locomotor activity were observed. These results indicate that RvE3, as well as RvE1 and RvE2, have antidepressant effects. (C) 2018 The Authors. Production and hosting by Elsevier B.V.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 南 雅文

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