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Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility
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Title: | Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility |
Authors: | Kajikawa, Mizuho Browse this author | Ose, Toyoyuki Browse this author | Fukunaga, Yuko Browse this author | Okabe, Yuki Browse this author | Matsumoto, Naoki Browse this author | Yonezawa, Kento Browse this author | Shimizu, Nobutaka Browse this author | Kollnberger, Simon Browse this author | Kasahara, Masanori Browse this author | Maenaka, Katsumi Browse this author →KAKEN DB |
Issue Date: | 18-Oct-2018 |
Publisher: | Nature Publishing Group |
Journal Title: | Nature communications |
Volume: | 9 |
Start Page: | 4330 |
Publisher DOI: | 10.1038/s41467-018-06797-8 |
Abstract: | The MILL family, composed of MILL1 and MILL2, is a group of nonclassical MHC class I molecules that occur in some orders of mammals. It has been reported that mouse MILL2 is involved in wound healing; however, the molecular mechanisms remain unknown. Here, we determine the crystal structure of MILL2 at 2.15 angstrom resolution, revealing an organization similar to classical MHC class I. However, the alpha 1-alpha 2 domains are not tightly fixed on the alpha 3-beta 2m domains, indicating unusual interdomain flexibility. The groove between the two helices in the alpha 1-alpha 2 domains is too narrow to permit ligand binding. Notably, an unusual basic patch on the alpha 3 domain is involved in the binding to heparan sulfate which is essential for MILL2 interactions with fibroblasts. These findings suggest that MILL2 has a unique structural architecture and physiological role, with binding to heparan sulfate proteoglycans on fibroblasts possibly regulating cellular recruitment in biological events. |
Rights: | http://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/72071 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 前仲 勝実
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