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Complement-independent blistering mechanisms in bullous pemphigoid

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Title: Complement-independent blistering mechanisms in bullous pemphigoid
Authors: Iwata, Hiroaki Browse this author →KAKEN DB
Ujiie, Hideyuki Browse this author →KAKEN DB
Keywords: bullous pemphigoid
collagen XVII
Issue Date: Dec-2017
Publisher: John Wiley & Sons
Journal Title: Experimental dermatology
Volume: 26
Issue: 12
Start Page: 1235
End Page: 1239
Publisher DOI: 10.1111/exd.13367
PMID: 28418613
Abstract: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that clinically demonstrates tense blisters with widespread erythema, histologically demonstrates subepidermal blistering and immunologically demonstrates the presence of circulating autoantibodies against hemidesmosomal molecules. Complement activation has long been regarded as necessary for the generation of the BP, However, certain evidence has recently come to support non-complemental blistering mechanisms. The story of BP blistering mechanisms is a complicated one. This review mainly focuses on a specific blistering mechanism that highlights the role of complements in BP blistering.
Rights: This is the peer reviewed version of the following article: Iwata H, Ujiie H. Complement‐independent blistering mechanisms in bullous pemphigoid. Exp Dermatol. 2017;26:1235–1239, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岩田 浩明

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