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Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes
| Title: | Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes |
| Other Titles: | non-NC16A bullous pemphigoid |
| Authors: | Imafuku, Keisuke Browse this author | | Iwata, Hiroaki Browse this author →KAKEN DB | | Kamaguchi, Mayumi Browse this author | | Izumi, Kentaro Browse this author →KAKEN DB | | Natsuga, Ken Browse this author →KAKEN DB | | Ujiie, Hideyuki Browse this author →KAKEN DB | | Nishie, Wataru Browse this author →KAKEN DB | | Shimizu, Hiroshi Browse this author →KAKEN DB |
| Keywords: | bullous pemphigoid | | depletion | | internalization | | non-collagenous 16A domain | | type XVII collagen |
| Issue Date: | Dec-2017 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Experimental dermatology |
| Volume: | 26 |
| Issue: | 12 |
| Start Page: | 1171 |
| End Page: | 1174 |
| Publisher DOI: | 10.1111/exd.13331 |
| PMID: | 28266727 |
| Abstract: | Type XVII collagen (COL17) and the non-collagenous 16A (NC16A) domain is regarded as the major pathogenic domains for bullous pemphigoid (BP). Some patients with BP have autoantibodies against parts of COL17 outside the NC16A domain (hereinafter the non-NC16A domain) and show less inflammatory manifestations. There were no significant differences in titres and IgG subclasses between NC16A-BP and non-NC16A-BP as determined by indirect immunofluorescent microscopy. The neutrophil activation capacities determined by ROS release did not differ between NC16A-BP and non-NC16A-BP. However, NC16A-BP IgG depleted COL17 in a dose-dependent manner. Treatment with NC16A-BP IgG, but not with non-NC16A-BP IgG, significantly decreased the adhesion strength. We speculate that the differences in clinical severity between NC16A-BP and non-NC16A-BP relate to the degree of COL17 depletion. |
| Description: | Special Issue: Thematic issue: New insights into pemphigoid diseases |
| Rights: | This is the peer reviewed version of the following article: Imafuku, K., Iwata, H., Kamaguchi, M., Izumi, K., Natsuga, K., Ujiie, H., Nishie, W. and Shimizu, H. (2017), Autoantibodies of non‐inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes. Exp Dermatol, 26: 1171-1174., which has been published in final form at https://doi.org/10.1111/exd.13331. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/72076 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岩田 浩明
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