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Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes

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Title: Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes
Other Titles: non-NC16A bullous pemphigoid
Authors: Imafuku, Keisuke Browse this author
Iwata, Hiroaki Browse this author →KAKEN DB
Kamaguchi, Mayumi Browse this author
Izumi, Kentaro Browse this author →KAKEN DB
Natsuga, Ken Browse this author →KAKEN DB
Ujiie, Hideyuki Browse this author →KAKEN DB
Nishie, Wataru Browse this author →KAKEN DB
Shimizu, Hiroshi Browse this author →KAKEN DB
Keywords: bullous pemphigoid
depletion
internalization
non-collagenous 16A domain
type XVII collagen
Issue Date: Dec-2017
Publisher: John Wiley & Sons
Journal Title: Experimental dermatology
Volume: 26
Issue: 12
Start Page: 1171
End Page: 1174
Publisher DOI: 10.1111/exd.13331
PMID: 28266727
Abstract: Type XVII collagen (COL17) and the non-collagenous 16A (NC16A) domain is regarded as the major pathogenic domains for bullous pemphigoid (BP). Some patients with BP have autoantibodies against parts of COL17 outside the NC16A domain (hereinafter the non-NC16A domain) and show less inflammatory manifestations. There were no significant differences in titres and IgG subclasses between NC16A-BP and non-NC16A-BP as determined by indirect immunofluorescent microscopy. The neutrophil activation capacities determined by ROS release did not differ between NC16A-BP and non-NC16A-BP. However, NC16A-BP IgG depleted COL17 in a dose-dependent manner. Treatment with NC16A-BP IgG, but not with non-NC16A-BP IgG, significantly decreased the adhesion strength. We speculate that the differences in clinical severity between NC16A-BP and non-NC16A-BP relate to the degree of COL17 depletion.
Description: Special Issue: Thematic issue: New insights into pemphigoid diseases
Rights: This is the peer reviewed version of the following article: Imafuku, K., Iwata, H., Kamaguchi, M., Izumi, K., Natsuga, K., Ujiie, H., Nishie, W. and Shimizu, H. (2017), Autoantibodies of non‐inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes. Exp Dermatol, 26: 1171-1174., which has been published in final form at https://doi.org/10.1111/exd.13331. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/72076
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岩田 浩明

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