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Photoinduced electron transfer reaction in mitochondria for spatiotemporal selective photo-oxidation of lipids by donor/acceptor linked molecules
| Title: | Photoinduced electron transfer reaction in mitochondria for spatiotemporal selective photo-oxidation of lipids by donor/acceptor linked molecules |
| Authors: | Takano, Yuta Browse this author | | Hanai, Erina Browse this author | | Imahori, Hiroshi Browse this author |
| Issue Date: | 7-Dec-2017 |
| Publisher: | Royal Society of Chemistry |
| Journal Title: | Nanoscale |
| Volume: | 9 |
| Issue: | 45 |
| Start Page: | 17909 |
| End Page: | 17913 |
| Publisher DOI: | 10.1039/c7nr04919f |
| Abstract: | Donor-acceptor-linked molecules have been synthesized and utilized to induce the rapid and site-selective lipid-oxidation in mitochondria by utilizing a photoinduced intermolecular electron transfer reaction. Two water-soluble donor-acceptor molecules (1 and 2) were designed and synthesized for this purpose. 2 was prepared to modulate its affinity to cell membrane in mitochondria. Confocal laser microscopy experiments revealed that 1 and 2 possess high localization abilities in mitochondria. By the photoinduced electron transfer, 2 exhibited the remarkable oxidation ability of lipids, mainly cardiolipin. In HeLa cells, 2 triggered mitochondrial lipid oxidation, which was followed by apoptotic cell death, under illumination within a few seconds. These results show that the present molecular system is highly promising to utilize the photoinduced intermolecular electron transfer reaction in a precise spatiotemporal manner in a cell by using light. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/72134 |
| Appears in Collections: | 電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 髙野 勇太
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