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Noninvasive electrical conductivity measurement by MRI: a test of its validity and the electrical conductivity characteristics of glioma

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/72269

Title: Noninvasive electrical conductivity measurement by MRI: a test of its validity and the electrical conductivity characteristics of glioma
Authors: Tha, Khin Khin Browse this author →KAKEN DB
Katscher, Ulrich Browse this author
Yamaguchi, Shigeru Browse this author
Stehning, Christian Browse this author
Terasaka, Shunsuke Browse this author →KAKEN DB
Fujima, Noriyuki Browse this author →KAKEN DB
Kudo, Kohsuke Browse this author →KAKEN DB
Kazumata, Ken Browse this author
Yamamoto, Toru Browse this author →KAKEN DB
Van Cauteren, Marc Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Electrical conductivity
Glioma
Magnetic resonance imaging
Steady-state free precession
Validity
Issue Date: Jan-2018
Publisher: Springer
Journal Title: European radiology
Volume: 28
Issue: 1
Start Page: 348
End Page: 355
Publisher DOI: 10.1007/s00330-017-4942-5
PMID: 28698943
Abstract: This study noninvasively examined the electrical conductivity (sigma) characteristics of diffuse gliomas using MRI and tested its validity. MRI including a 3D steady-state free precession (3D SSFP) sequence was performed on 30 glioma patients. The sigma maps were reconstructed from the phase images of the 3D SSFP sequence. The sigma histogram metrics were extracted and compared among the contrast-enhanced (CET) and noncontrast-enhanced tumour components (NCET) and normal brain parenchyma (NP). Difference in tumour sigma histogram metrics among tumour grades and correlation of sigma metrics with tumour grades were tested. Validity of sigma measurement using this technique was tested by correlating the mean tumour sigma values measured using MRI with those measured ex vivo using a dielectric probe. Several sigma histogram metrics of CET and NCET of diffuse gliomas were significantly higher than NP (Bonferroni-corrected p ae<currency> .045). The maximum sigma of NCET showed a moderate positive correlation with tumour grade (r = .571, Bonferroni-corrected p = .018). The mean tumour sigma measured using MRI showed a moderate positive correlation with the sigma measured ex vivo (r = .518, p = .040). Tissue sigma can be evaluated using MRI, incorporation of which may better characterise diffuse gliomas. aEuro cent This study tested the validity of noninvasive electrical conductivity measurements by MRI. aEuro cent This study also evaluated the electrical conductivity characteristics of diffuse glioma. aEuro cent Gliomas have higher electrical conductivity values than the normal brain parenchyma. aEuro cent Noninvasive electrical conductivity measurement can be helpful for better characterisation of glioma.
Rights: This is a post-peer-review, pre-copyedit version of an article published in European Radiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00330-017-4942-5
Type: bookchapter (author version)
URI: http://hdl.handle.net/2115/72269
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Khin Khin Tha

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