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Dietary intakes of fat soluble vitamins as predictors of mortality from heart failure in a large prospective cohort study

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Title: Dietary intakes of fat soluble vitamins as predictors of mortality from heart failure in a large prospective cohort study
Other Titles: Fat soluble vitamins and heart failure death
Authors: Eshak, Ehab S. Browse this author
Iso, Hiroyasu Browse this author →KAKEN DB
Yamagishi, Kazumasa Browse this author
Cui, Renzhe Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Dietary vitamin A
Dietary vitamin K
Dietary vitamin E
Dietary vitamin D
Heart failure mortality
Japanese
Issue Date: Mar-2018
Publisher: Elsevier
Journal Title: Nutrition
Volume: 47
Start Page: 50
End Page: 55
Publisher DOI: 10.1016/j.nut.2017.09.009
PMID: 29429535
Abstract: Objective: A few reports have investigated the association of dietary vitamin intakes with risk of heart failure in Asia. Therefore, we examined the relation of dietary intakes of fat-soluble vitamins A, K E, and D with mortality from heart failure in Japanese population. Research Methods and Procedures: A total of 23,099 men and 35,597 women aged 40-79 years participated in the Japan Collaborative Cohort Study and completed a food frequency questionnaire, from which dietary intakes of vitamin A, K, E and D were calculated. Cox proportional hazard model was used to estimate the sex-specific risk of heart failure mortality according to increasing quintiles of fat soluble vitamin intakes. Results: During median 19.3-year follow-up, there were 567 deaths from heart failure (395 men and 307 women). Dietary vitamin A intake showed no association with heart failure mortality in both genders; contrary, the reduced risk was observed in women but not in men with dietary intakes of vitamin K, E and D. The multivariable HRs (95% CI) in the highest versus the lowest intake quintiles among women were 0.63 (0.45, 0.87; P for trend=0.006) for vitamin K, 0.55 (0.36, 0.78; P for trend=0.006) for vitamin E and 0.66 (0.48, 0.93; P for trend= 0.01) for vitamin D. The association for each vitamin was slightly attenuated but remained statistically significant after mutual adjustment for other vitamins. Conclusions: High dietary intakes of fat soluble vitamins K, E and D were associated with reduced risk of heart failure mortality in Japanese women but not men.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/72728
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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