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Volume 67 Number 1 >

Rearing and breeding of germ-free mice for over 1 year in a sealed positive pressure cage system

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Title: Rearing and breeding of germ-free mice for over 1 year in a sealed positive pressure cage system
Authors: Niimi, Kimie Browse this author
Hardy, Patrick Browse this author
Bilecki, Brian Browse this author
Takahashi, Eiki Browse this author
Keywords: Germ-free mouse
Rearing and breeding
Sealed positive pressure isolation cage
Issue Date: Feb-2019
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 67
Issue: 1
Start Page: 119
End Page: 125
Abstract: Germ-free mice and gnotobiotic mice have long been used as models in various research areas. Historically, they were reared and used for studies of flexible film isolators, but such isolators have several operational disadvantages. To overcome these disadvantages, a new individually ventilated cage system that promises more standardized cage conditions and reduced operational costs for maintaining germ-free or gnotobiotic mice has been developed. However, in the context of this system, only short periods (2-12 weeks) of rearing and experimental use of germ-free or gnotobiotic mice have been reported. In this report, we describe the rearing and breeding of 117 germ-free mice for over 1 year using the Sentry SPP cage, a sealed positive pressure isolation cage dedicated to gnotobiology.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 67 Number 1

Submitter: 獣医学部図書室

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