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Predictive factors for hyperglycaemic progression in patients with schizophrenia or bipolar disorder

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Title: Predictive factors for hyperglycaemic progression in patients with schizophrenia or bipolar disorder
Authors: Kusumi, Ichiro Browse this author →KAKEN DB
Arai, Yuki Browse this author
Okubo, Ryo Browse this author
Honda, Minoru Browse this author
Matsuda, Yasuhiro Browse this author
Matsuda, Yukihiko Browse this author
Tochigi, Akihiko Browse this author
Takekita, Yoshiteru Browse this author
Yamanaka, Hiroyoshi Browse this author
Uemura, Keiichi Browse this author
Ito, Koichi Browse this author
Tsuchiya, Kiyoshi Browse this author
Yamada, Jun Browse this author
Yoshimura, Bunta Browse this author
Mitsui, Nobuyuki Browse this author
Matsubara, Sigehiro Browse this author
Segawa, Takayuki Browse this author
Nishi, Nobuyuki Browse this author
Sugawara, Yasufumi Browse this author
Kako, Yuki Browse this author →KAKEN DB
Shinkawa, Ikuta Browse this author
Shinohara, Kaoru Browse this author
Konishi, Akiko Browse this author
Iga, Junichi Browse this author
Hashimoto, Naoki Browse this author
Inomata, Shinsaku Browse this author
Tsukamoto, Noriko Browse this author
Ito, Hiroto Browse this author
Ito, Yoichi M. Browse this author →KAKEN DB
Sato, Norihiro Browse this author
Keywords: Schizophrenia
bipolar disorder
Issue Date: Nov-2018
Publisher: Cambridge University Press
Journal Title: BJPsych Open
Volume: 4
Issue: 6
Start Page: 454
End Page: 460
Publisher DOI: 10.1192/bjo.2018.56
Abstract: Background: Patients with schizophrenia or bipolar disorder have a high risk of developing type 2 diabetes. Aims: To identify predictive factors for hyperglycaemic progression in individuals with schizophrenia or bipolar disorder and to determine whether hyperglycaemic progression rates differ among antipsychotics in regular clinical practice. Method: We recruited 1166 patients who initially had normal or prediabetic glucose levels for a nationwide, multisite, l-year prospective cohort study to determine predictive factors for hyperglycaemic progression. We also examined whether hyperglycaemic progression varied among patients receiving monotherapy with the six most frequently used antipsychotics. Results: High baseline serum triglycerides and coexisting hypertension significantly predicted hyperglycaemic progression. The six most frequently used antipsychotics did not significantly differ in their associated hyperglycaemic progression rates over the 1-year observation period. Conclusions: Clinicians should carefully evaluate baseline serum triglycerides and coexisting hypertension and perform strict longitudinal monitoring irrespective of the antipsychotic used.
Rights: © The Royal College of Psychiatrists 2018
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久住 一郎

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