| Title: | Predictive factors for hyperglycaemic progression in patients with schizophrenia or bipolar disorder |
| Authors: | Kusumi, Ichiro Browse this author →KAKEN DB |
| Arai, Yuki Browse this author |
| Okubo, Ryo Browse this author |
| Honda, Minoru Browse this author |
| Matsuda, Yasuhiro Browse this author |
| Matsuda, Yukihiko Browse this author |
| Tochigi, Akihiko Browse this author |
| Takekita, Yoshiteru Browse this author |
| Yamanaka, Hiroyoshi Browse this author |
| Uemura, Keiichi Browse this author |
| Ito, Koichi Browse this author |
| Tsuchiya, Kiyoshi Browse this author |
| Yamada, Jun Browse this author |
| Yoshimura, Bunta Browse this author |
| Mitsui, Nobuyuki Browse this author |
| Matsubara, Sigehiro Browse this author |
| Segawa, Takayuki Browse this author |
| Nishi, Nobuyuki Browse this author |
| Sugawara, Yasufumi Browse this author |
| Kako, Yuki Browse this author →KAKEN DB |
| Shinkawa, Ikuta Browse this author |
| Shinohara, Kaoru Browse this author |
| Konishi, Akiko Browse this author |
| Iga, Junichi Browse this author |
| Hashimoto, Naoki Browse this author |
| Inomata, Shinsaku Browse this author |
| Tsukamoto, Noriko Browse this author |
| Ito, Hiroto Browse this author |
| Ito, Yoichi M. Browse this author →KAKEN DB |
| Sato, Norihiro Browse this author |
| Keywords: | Schizophrenia |
| bipolar disorder |
| diabetes |
| monitoring |
| Issue Date: | Nov-2018 |
| Publisher: | Cambridge University Press |
| Journal Title: | BJPsych Open |
| Volume: | 4 |
| Issue: | 6 |
| Start Page: | 454 |
| End Page: | 460 |
| Publisher DOI: | 10.1192/bjo.2018.56 |
| Abstract: | Background: Patients with schizophrenia or bipolar disorder have a high risk of developing type 2 diabetes. Aims: To identify predictive factors for hyperglycaemic progression in individuals with schizophrenia or bipolar disorder and to determine whether hyperglycaemic progression rates differ among antipsychotics in regular clinical practice. Method: We recruited 1166 patients who initially had normal or prediabetic glucose levels for a nationwide, multisite, l-year prospective cohort study to determine predictive factors for hyperglycaemic progression. We also examined whether hyperglycaemic progression varied among patients receiving monotherapy with the six most frequently used antipsychotics. Results: High baseline serum triglycerides and coexisting hypertension significantly predicted hyperglycaemic progression. The six most frequently used antipsychotics did not significantly differ in their associated hyperglycaemic progression rates over the 1-year observation period. Conclusions: Clinicians should carefully evaluate baseline serum triglycerides and coexisting hypertension and perform strict longitudinal monitoring irrespective of the antipsychotic used. |
| Rights: | © The Royal College of Psychiatrists 2018 |
| https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/72975 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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