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Olefin-accelerated solid-state C-N cross-coupling reactions using mechanochemistry

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Title: Olefin-accelerated solid-state C-N cross-coupling reactions using mechanochemistry
Authors: Kubota, Koji Browse this author
Seo, Tamae Browse this author
Koide, Katsumasa Browse this author
Hasegawa, Yasuchika Browse this author →KAKEN DB
Ito, Hajime Browse this author →KAKEN DB
Issue Date: 10-Jan-2019
Publisher: Nature Publishing Group
Journal Title: Nature communications
Volume: 10
Start Page: 111
Publisher DOI: 10.1038/s41467-018-08017-9
Abstract: Palladium-catalyzed cross-coupling reactions are one of the most powerful and versatile methods to synthesize a wide range of complex functionalized molecules. However, the development of solid-state cross-coupling reactions remains extremely limited. Here, we report a rational strategy that provides a general entry to palladium-catalyzed Buchwald-Hartwig cross-coupling reactions in the solid state. The key finding of this study is that olefin additives can act as efficient molecular dispersants for the palladium-based catalyst in solid-state media to facilitate the challenging solid-state cross-coupling. Beyond the immediate utility of this protocol, our strategy could inspire the development of industrially attractive solvent-free palladium-catalyzed cross-coupling processes for other valuable synthetic targets.
Type: article
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久保田 浩司

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