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Singing activity-driven Arc expression associated with vocal acoustic plasticity in juvenile songbird

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Title: Singing activity-driven Arc expression associated with vocal acoustic plasticity in juvenile songbird
Authors: Hayase, Shin Browse this author
Wada, Kazuhiro Browse this author →KAKEN DB
Keywords: immediate early gene
learning efficiency
motor learning
sensitive period
Issue Date: Jul-2018
Publisher: John Wiley & Sons
Journal Title: European journal of neuroscience
Volume: 48
Issue: 2
Start Page: 1728
End Page: 1742
Publisher DOI: 10.1111/ejn.14057
Abstract: Learned vocalization, including birdsong and human speech, is acquired through self-motivated vocal practice during the sensitive period of vocal learning. The zebra finch (Taeniopygia guttata) develops a song characterized by vocal variability and crystallizes a defined song pattern as adulthood. However, it remains unknown how vocal variability is regulated with diurnal singing during the sensorimotor learning period. Here, we investigated the expression of activity-dependent neuroplasticity-related gene Arc during the early plastic song phase to examine its potential association with vocal plasticity. We first confirmed that multiple acoustic features of syllables in the plastic song were dramatically and simultaneously modulated during the first 3 hr of singing in a day and the altered features were maintained until sleep. In a concurrent manner, Arc was intensely induced during morning singing and a subsequent attenuation during afternoon singing in the robust nucleus of the arcopallium (RA) and the interfacial nucleus of the nidopallium (NIf). The singing-driven Arc expression was not altered by circadian rhythm, but rather reduced during the day as juveniles produced more songs. Song stabilization accelerated by testosterone administration in juveniles was accompanied with attenuation of Arc induction in RA and NIf. In contrast, although early-deafened birds produced highly unstable song even at adulthood, singing-driven Arc expression was not different between intact and early-deafened adults. These results suggest a potential functional link between Arc expression in RA and NIf and vocal plasticity during the sensorimotor phase of song learning. Nonetheless, Arc expression did not reflect the quality of bird's own song or auditory feedback.
Rights: This is the peer reviewed version of the following article: European Journal of Neuroscience, Volume48, Issue2 July 2018, Pages 1728-1742, which has been published in final form at . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 和多 和宏

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