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Vocal practice regulates singing activity-dependent genes underlying age-independent vocal learning in songbirds
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Vocal practice regulates singing activity-dependent genes underlying age-independent vocal learning in songbirds |
| Authors: | Hayase, Shin Browse this author | | Wang, Hongdi Browse this author | | Ohgushi, Eri Browse this author | | Kobayashi, Masahiko Browse this author | | Mori, Chihiro Browse this author | | Horita, Haruhito Browse this author | | Mineta, Katsuhiko Browse this author →KAKEN DB | | Liu, Wan-chun Browse this author | | Wada, Kazuhiro Browse this author →KAKEN DB |
| Keywords: | Bird song | | Birds | | Neuronal dendrites | | Learning | | Syllables | | Gene regulation | | Zebra finch | | Bird genetics |
| Issue Date: | Sep-2018 |
| Publisher: | PLOS |
| Journal Title: | PLoS biology |
| Volume: | 16 |
| Issue: | 9 |
| Start Page: | e2006537 |
| Publisher DOI: | 10.1371/journal.pbio.2006537 |
| Abstract: | The development of highly complex vocal skill, like human language and bird songs, is underlain by learning. Vocal learning, even when occurring in adulthood, is thought to largely depend on a sensitive/critical period during postnatal development, and learned vocal patterns emerge gradually as the long-term consequence of vocal practice during this critical period. In this scenario, it is presumed that the effect of vocal practice is thus mainly limited by the intrinsic timing of age-dependent maturation factors that close the critical period and reduce neural plasticity. However, an alternative, as-yet untested hypothesis is that vocal practice itself, independently of age, regulates vocal learning plasticity. Here, we explicitly discriminate between the influences of age and vocal practice using a songbird model system. We prevented zebra finches from singing during the critical period of sensorimotor learning by reversible postural manipulation. This enabled to us to separate lifelong vocal experience from the effects of age. The singing-prevented birds produced juvenile-like immature song and retained sufficient ability to acquire a tutored song even at adulthood when allowed to sing freely. Genome-wide gene expression network analysis revealed that this adult vocal plasticity was accompanied by an intense induction of singing activity-dependent genes, similar to that observed in juvenile birds, rather than of age-dependent genes. The transcriptional changes of activity-dependent genes occurred in the vocal motor robust nucleus of the arcopallium (RA) projection neurons that play a critical role in the production of song phonology. These gene expression changes were accompanied by neuroanatomical changes: dendritic spine pruning in RA projection neurons. These results show that self-motivated practice itself changes the expression dynamics of activity-dependent genes associated with vocal learning plasticity and that this process is not tightly linked to age-dependent maturational factors. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/73008 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 和多 和宏
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