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Vocal practice regulates singing activity-dependent genes underlying age-independent vocal learning in songbirds

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Title: Vocal practice regulates singing activity-dependent genes underlying age-independent vocal learning in songbirds
Authors: Hayase, Shin Browse this author
Wang, Hongdi Browse this author
Ohgushi, Eri Browse this author
Kobayashi, Masahiko Browse this author
Mori, Chihiro Browse this author
Horita, Haruhito Browse this author
Mineta, Katsuhiko Browse this author →KAKEN DB
Liu, Wan-chun Browse this author
Wada, Kazuhiro Browse this author →KAKEN DB
Keywords: Bird song
Birds
Neuronal dendrites
Learning
Syllables
Gene regulation
Zebra finch
Bird genetics
Issue Date: Sep-2018
Publisher: PLOS
Journal Title: PLoS biology
Volume: 16
Issue: 9
Start Page: e2006537
Publisher DOI: 10.1371/journal.pbio.2006537
Abstract: The development of highly complex vocal skill, like human language and bird songs, is underlain by learning. Vocal learning, even when occurring in adulthood, is thought to largely depend on a sensitive/critical period during postnatal development, and learned vocal patterns emerge gradually as the long-term consequence of vocal practice during this critical period. In this scenario, it is presumed that the effect of vocal practice is thus mainly limited by the intrinsic timing of age-dependent maturation factors that close the critical period and reduce neural plasticity. However, an alternative, as-yet untested hypothesis is that vocal practice itself, independently of age, regulates vocal learning plasticity. Here, we explicitly discriminate between the influences of age and vocal practice using a songbird model system. We prevented zebra finches from singing during the critical period of sensorimotor learning by reversible postural manipulation. This enabled to us to separate lifelong vocal experience from the effects of age. The singing-prevented birds produced juvenile-like immature song and retained sufficient ability to acquire a tutored song even at adulthood when allowed to sing freely. Genome-wide gene expression network analysis revealed that this adult vocal plasticity was accompanied by an intense induction of singing activity-dependent genes, similar to that observed in juvenile birds, rather than of age-dependent genes. The transcriptional changes of activity-dependent genes occurred in the vocal motor robust nucleus of the arcopallium (RA) projection neurons that play a critical role in the production of song phonology. These gene expression changes were accompanied by neuroanatomical changes: dendritic spine pruning in RA projection neurons. These results show that self-motivated practice itself changes the expression dynamics of activity-dependent genes associated with vocal learning plasticity and that this process is not tightly linked to age-dependent maturational factors.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/73008
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 和多 和宏

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