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Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus : A large population-based prospective cohort study

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Title: Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus : A large population-based prospective cohort study
Authors: Eshak, Ehab S. Browse this author
Iso, Hiroyasu Browse this author →KAKEN DB
Maruyama, Koutatsu Browse this author
Muraki, Isao Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Cohort study
Copper
Iron
Japanese
Type 2 diabetes mellitus
Zinc
Issue Date: Apr-2018
Publisher: Elsevier
Journal Title: Clinical nutrition
Volume: 37
Issue: 2
Start Page: 667
End Page: 674
Publisher DOI: 10.1016/j.clnu.2017.02.010
Abstract: Background & aims: Abnormal homeostasis of iron, copper and zinc has been included in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the evidence of associations between dietary intakes of these elements and T2DM is limited. We thought to examine the association between dietary intakes of iron, copper and zinc with risk of T2DM in Japanese population. Methods: A prospective study encompassing 16,160 healthy Japanese men and women aged 40-65 years in whom the associations between dietary intakes of iron, copper and zinc, determined by a validated self-administered food frequency questionnaire, with risk of 5-year cumulative incidence of validated physician-diagnosed T2DM, were evaluated by logistic regression model. Results: We ascertained 396 self-reported new cases of diabetes within 5-year period. Dietary intakes of iron (total and nonheme but not heme iron) and copper were positively associated with risk of T2DM; the multivariable OR in the highest versus lowest quartiles of intakes were 1.32 (1.04, 1.70; P-trend = 0.03) and 1.55 (1.13, 2.02; P-trend = 0.003), respectively. These associations were more evident in the high risk group; older, overweight, smokers and those with family history of diabetes. The dietary intake of zinc was inversely associated with risk of T2DM; the multivariable OR was 0.64 (0.54, 1.00; P-trend = 0.003), and such association was evident among younger subjects (age 40-55 years) only. Conclusions: Dietary intakes of iron and copper were associated with a higher risk, while dietary intake of zinc was associated with a reduced risk of T2DM in Japanese population.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/73415
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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