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Discovery and genetic characterization of diverse smacoviruses in Zambian non-human primates.

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Title: Discovery and genetic characterization of diverse smacoviruses in Zambian non-human primates.
Authors: Anindita, Paulina D Browse this author
Sasaki, Michihito Browse this author →KAKEN DB
Gonzalez, Gabriel Browse this author
Phongphaew, Wallaya Browse this author
Carr, Michael Browse this author →KAKEN DB
Hang'ombe, Bernard M Browse this author
Mweene, Aaron S Browse this author
Ito, Kimihito Browse this author →KAKEN DB
Orba, Yasuko Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Issue Date: 8-Apr-2019
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 9
Issue: 1
Start Page: 5045
Publisher DOI: 10.1038/s41598-019-41358-z
PMID: 30962460
Abstract: The Smacoviridae has recently been classified as a family of small circular single-stranded DNA viruses. An increasing number of smacovirus genomes have been identified exclusively in faecal matter of various vertebrate species and from insect body parts. However, the genetic diversity and host range of smacoviruses remains to be fully elucidated. Herein, we report the genetic characterization of eleven circular replication-associated protein (Rep) encoding single-stranded (CRESS) DNA viruses detected in the faeces of Zambian non-human primates. Based on pairwise genome-wide and amino acid identities with reference smacovirus species, ten of the identified CRESS DNA viruses are assigned to the genera Porprismacovirus and Huchismacovirus of the family Smacoviridae, which bidirectionally encode two major open reading frames (ORFs): Rep and capsid protein (CP) characteristic of a type IV genome organization. The remaining unclassified CRESS DNA virus was related to smacoviruses but possessed a genome harbouring a unidirectionally oriented CP and Rep, assigned as a type V genome organization. Moreover, phylogenetic and recombination analyses provided evidence for recombination events encompassing the 3'-end of the Rep ORF in the unclassified CRESS DNA virus. Our findings increase the knowledge of the known genetic diversity of smacoviruses and highlight African non-human primates as carrier animals.
Type: article
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐々木 道仁

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