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Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size : The Hokkaido Study on environment and children's health

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Title: Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size : The Hokkaido Study on environment and children's health
Authors: Minatoya, Machiko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Miura, Ryu Browse this author
Goudarzi, Houman Browse this author →KAKEN DB
Iwasaki, Yusuke Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Adiponectin
Birth cohort
Issue Date: Jul-2017
Publisher: Elsevier
Journal Title: Environmental research
Volume: 156
Start Page: 175
End Page: 182
Publisher DOI: 10.1016/j.envres.2017.03.033
PMID: 28349882
Abstract: Perfluoroalkyl substances (PFASs) are synthetic chemicals that persist in the environment and in humans. There is a possible association between prenatal PFASs exposure and both neonate adipokines and birth size, yet epidemiological studies are very limited. The objective of this study was to examine associations of prenatal exposure to PFASs with cord blood adipokines and birth size. We conducted birth cohort study, the Hokkaido Study. In this study, 168 mother-child pairs were included. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in maternal blood were determined by liquid chromatography tandem mass spectrometry. Cord blood adiponectin and leptin levels were measured by ELISA and RIA, respectively. Birth weight and ponderal index (PI) were obtained from birth record. The median maternal PFOS and PFOA were 5.1 and 1.4 ng/mL, respectively. The median total adiponectin and leptin levels were 19.4 μg/mL and 6.2 ng/mL, respectively. Adjusted linear regression analyses found that PFOS level was positively associated with total adiponectin levels (β=0.12, 95% CI:0.01, 0.22), contrary was negatively associated with PI (β=-2.25, 95% CI: -4.01, -0.50). PFOA level was negatively associated with birth weight (β=-197, 95% CI: -391, -3). Leptin levels were not associated with PFASs levels. PFOS and adiponectin levels showed marginal dose-response relationship and both PFOS and PFOA and birth size showed significant dose-response relationships. Results from this study suggested that prenatal PFASs exposure may alter cord blood adiponectin levels and may decrease birth size.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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