HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Science / Faculty of Science >
Peer-reviewed Journal Articles, etc >

Synthetic study of andrastins : stereoselective construction of the BCD-ring system

Files in This Item:
J ANTIBIOT20190116.pdf811.5 kBPDFView/Open
J ANTIBIOT20190116_supple.info.pdf1.21 MBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/74930

Title: Synthetic study of andrastins : stereoselective construction of the BCD-ring system
Authors: Yoshimura, Fumihiko Browse this author →KAKEN DB
Abe, Taiki Browse this author
Ishioka, Yuichi Browse this author
Tanino, Keiji Browse this author
Issue Date: 16-Jan-2019
Journal Title: The Journal of Antibiotics
Volume: 72
Start Page: 384
End Page: 388
Publisher DOI: 10.1038/s41429-018-0136-x
Abstract: Andrastins are meroterpenes isolated from Penicillium sp. FO-3929 that display highly potent inhibitory activities toward protein farnesyltransferase. Structurally, they possess a unique steroidal tetracyclic skeleton (the ABCD-ring) with three contiguous quaternary stereocenters on the C-ring. Herein, we describe our nitrile cyclization-based approach to the stereoselective construction of the BCD-ring system of andrastins, which contains three contiguous quaternary stereocenters on the C-ring and the correct oxidation states of the D-ring.
Type: article (author version)
URI: http://hdl.handle.net/2115/74930
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉村 文彦

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University