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H13 influenza viruses in wild birds have undergone genetic and antigenic diversification in nature

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Title: H13 influenza viruses in wild birds have undergone genetic and antigenic diversification in nature
Authors: Wang, Zu-Jyun Browse this author
Kikutani, Yuto Browse this author
Lam Thanh Nguyen Browse this author
Hiono, Takahiro Browse this author →KAKEN DB
Matsuno, Keita Browse this author →KAKEN DB
Okamatsu, Masatoshi Browse this author →KAKEN DB
Krauss, Scott Browse this author
Webby, Richard Browse this author
Lee, Youn-Jeong Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Sakoda, Yoshihiro Browse this author →KAKEN DB
Keywords: Avian influenza
H13 subtype
Issue Date: Aug-2018
Publisher: Springer
Journal Title: Virus Genes
Volume: 54
Issue: 4
Start Page: 543
End Page: 549
Publisher DOI: 10.1007/s11262-018-1573-0
PMID: 29796944
Abstract: Among 16 haemagglutinin (HA) subtypes of avian influenza viruses (AIVs), H13 AIVs have rarely been isolated in wild waterfowl. H13 AIVs cause asymptomatic infection and are maintained mainly in gull and tern populations; however, the recorded antigenic information relating to the viruses has been limited. In this study, 2 H13 AIVs, A/duck/Hokkaido/W345/2012 (H13N2) and A/duck/Hokkaido/WZ68/2012 (H13N2), isolated from the same area in the same year in our surveillance, were genetically and antigenically analyzed with 10 representative H13 strains including a prototype strain, A/gull/Maryland/704/1977 (H13N6). The HA genes of H13 AIVs were phylogenetically divided into 3 groups (I, II, and III). A/duck/Hokkaido/W345/2012 (H13N2) was genetically classified into Group III. This virus was distinct from a prototype strain, A/gull/Maryland/704/1977 (H13N6), and the virus, A/duck/Hokkaido/WZ68/2012 (H13N2), both belonging to Group I. Antigenic analysis indicated that the viruses of Group I were antigenically closely related to those of Group II, but distinct from those of Group III, including A/duck/Hokkaido/W345/2012 (H13N2). In summary, our study indicates that H13 AIVs have undergone antigenic diversification in nature.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Virus Genes. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 迫田 義博

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