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Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species

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Title: Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species
Authors: Fukuhara, Hideo Browse this author
Ito, Yuri Browse this author
Sako, Miyuki Browse this author
Kajikawa, Mizuho Browse this author
Yoshida, Koki Browse this author
Seki, Fumio Browse this author
Mwaba, Mwila Hilton Browse this author
Hashiguchi, Takao Browse this author
Higashibata, Masa-aki Browse this author
Ose, Toyoyuki Browse this author
Kuroki, Kimiko Browse this author →KAKEN DB
Takeda, Makoto Browse this author
Maenaka, Katsumi Browse this author →KAKEN DB
Keywords: morbillivirus
canine distemper virus
measles virus
surface plasmon resonance
Issue Date: Aug-2019
Publisher: MDPI
Journal Title: Viruses-Basel
Volume: 11
Issue: 8
Start Page: 761
Publisher DOI: 10.3390/v11080761
PMID: 31430904
Abstract: Measles virus (MV) and canine distemper virus (CDV) are highly contagious and deadly, forming part of the morbillivirus genus. The receptor recognition by morbillivirus hemagglutinin (H) is important for determining tissue tropism and host range. Recent reports largely urge caution as regards to the potential expansion of host specificities of morbilliviruses. Nonetheless, the receptor-binding potential in different species of morbillivirus H proteins is largely unknown. Herein, we show that the CDV-H protein binds to the dog signaling lymphocyte activation molecule (SLAM), but not to the human, tamarin, or mouse SLAM. In contrast, MV-H can bind to human, tamarin and dog SLAM, but not to that of mice. Notably, MV binding to dog SLAM showed a lower affinity and faster kinetics than that of human SLAM, and MV exhibits a similar entry activity in dog SLAM- and human SLAM-expressing Vero cells. The mutagenesis study using a fusion assay, based on the MV-H-SLAM complex structure, revealed differences in tolerance for the receptor specificity between MV-H and CDV-H. These results provide insights into H-SLAM specificity related to potential host expansion.
Rights: © 2019 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution License (
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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