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EPR-based oximetric imaging : a combination of single point-based spatial encoding and T1 weighting

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Title: EPR-based oximetric imaging : a combination of single point-based spatial encoding and T1 weighting
Authors: Matsumoto, Ken-ichiro Browse this author
Kishimoto, Shun Browse this author
Devasahayam, Nallathamby Browse this author
Chandramouli, Gadisetti V. R. Browse this author
Ogawa, Yukihiro Browse this author
Matsumoto, Shingo Browse this author →KAKEN DB
Krishna, Murali C. Browse this author
Subramanian, Sankaran Browse this author
Keywords: EPR imaging
EPR oximetry
in vivo oximetry
partial oxygen pressure
single-point imaging
spin-lattice relaxation time
triphenylmethyl radical
tissue oxygen
Issue Date: Nov-2018
Publisher: Wiley
Journal Title: Magnetic Resonance in Medicine
Volume: 80
Issue: 5
Start Page: 2275
End Page: 2287
Publisher DOI: 10.1002/mrm.27182
Abstract: Purpose: Spin-lattice relaxation time (T1)-weighted time-domain EPR oximetry is reported for in vivo applications using a paramagnetic probe, a trityl-based Oxo71. Methods: The R1 dependence of the trityl probe Oxo71 on pO2 was assessed using single point imaging (SPI) mode of spatial encoding combined with rapid repetition, similar to T1-weighted MRI, where R1 was determined from 22 repetition times ranging from 2.1–40.0 μs at 300 MHz. The pO2 maps of a phantom with three tubes containing 2 mM Oxo71 solutions equilibrated at 0%, 2%, and 5% oxygen were determined by R1 and apparent spin-spin relaxation rate (R2*) simultaneously. Results: The pO2 maps derived from R1 and R2* agreed with the known pO2 levels in the tubes of Oxo71. However, the histograms of pO2 revealed that R1 offers better pO2 resolution than R2* in low pO2 regions. The standard deviations of pixels at 2% pO2 (15.2 mmHg) were about 5 times lower in R1-based estimation than R2*-based estimation (mean ± SD: 13.9 ± 1.77 mmHg and 18.3 ± 8.70 mmHg, respectively). The in vivo pO2 map obtained from R1-based assessment displayed a homogeneous profile in low pO2 regions in tumor xenografts, consistent with previous reports on R2*-based oximetric imaging. The scan time to obtain the R1 map can be significantly reduced using three repetition times ranging from 4.0‒12.0 μs. Conclusion: Using the SPI modality, R1-based oximetry imaging with useful spatial and oxygen resolutions for small animals was demonstrated.
Rights: This is the peer reviewed version of the following article: Matsumoto K‐i, Kishimoto S, Devasahayam N, et al. EPR‐based oximetric imaging: a combination of single point‐based spatial encoding and T1 weighting. Magn Reson Med. 2018;80(5):2275-2287., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松元 慎吾

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