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Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months : The Hokkaido Study on Environment and Children's Health

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Title: Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months : The Hokkaido Study on Environment and Children's Health
Authors: Yamazaki, Keiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Nakajima, Sonomi Browse this author
Miyashita, Chihiro Browse this author →KAKEN DB
Ikeno, Tamiko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Minatoya, Machiko Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Mizutani, Futoshi Browse this author
Chisaki, Yoichi Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Neurodevelopment
Bayley Scales of Infant Development (BSID-II)
Organochlorine pesticide
Prenatal exposure
Birth cohort
Issue Date: Dec-2018
Publisher: Elsevier
Journal Title: NeuroToxicology
Volume: 69
Start Page: 201
End Page: 208
Publisher DOI: 10.1016/j.neuro.2017.11.011
Abstract: Organochlorine pesticides (OCPs) are environmental contaminants that persist in the environment and bioaccumulate through the food chain in humans and animals. Although previous studies have shown an association between prenatal OCP exposure and subsequent neurodevelopment, the levels of OCPs included in these studies were inconsistent. A hospital-based prospective birth cohort study was conducted to examine the associations between prenatal exposure to relatively low levels of OCPs and neurodevelopment in infants at 6 (n = 164) and 18 (n = 115) months of age. Blood samples were analyzed using gas chromatography/mass spectrometry techniques to quantify 29 OCPs. The Bayley Scales of Infant Development 2nd edition (BSID-II) was used to assess the Mental and Psychomotor Developmental Index. After controlling for confounders, we found an inverse association between prenatal exposure to cis-heptachlor epoxide and the Mental Developmental Index at 18 months of age. Furthermore, infants born to mothers with prenatal concentrations of cis-heptachlor epoxide in the highest quartile had Mental Developmental Index scores -9.8 (95% confidence interval: -16.4, -3.1) lower than that recorded for infants born to mothers with concentrations of cis-heptachlor epoxide in the first quartile (p for trend < 0.01). These results support the hypothesis that prenatal exposure to OCPs, especially cis-heptachlor epoxide, may have an adverse effect on the neurodevelopment of infants at specific ages, even at low levels.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/76214
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山﨑 圭子

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