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Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years : The Hokkaido study

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Title: Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years : The Hokkaido study
Authors: Miyashita, Chihiro Browse this author →KAKEN DB
Ait Bamai, Yu Browse this author
Araki, Atsuko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Minatoya, Machiko Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Kajiwara, Jumboku Browse this author
Hori, Tsuguhide Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Dioxin-like compounds
Prenatal exposure
IgE
Allergy
Infection
Children of school age
Issue Date: 1-Jan-2018
Publisher: Elsevier
Journal Title: Science of The Total Environment
Volume: 610-611
Start Page: 191
End Page: 199
Publisher DOI: 10.1016/j.scitotenv.2017.07.248
Abstract: Introduction: In utero exposure to dioxin-like compounds (DLCs) may cause imbalance of immune development in early infancy. However, there are few epidemiological studies into the effects of in utero exposure to DLCs on allergies and infections during childhood. This study evaluates associations between concentrations of maternal DLCs and cord blood immunoglobulin (Ig) E, as well as allergies and infections during childhood. Method: We recruited 514 pregnant women in a maternity hospital in Sapporo, Japan, and measured concentrations of DLCs in 426 maternal blood samples using high-resolution gas chromatography/high-resolution mass spectrometry. We examined the relationship between concentrations of maternal DLCs and cord blood IgE at birth (n = 239), as well as for allergies and infections in children at 3.5 (n = 327) and 7 (n = 264) years, using regression analysis adjusted for confounding variables. Results: We found a positive association between maternal DLC concentrations and frequency of wheezing in children aged up to 7 years [odds ratio (OR); 7.81 (95% confidence interval (CI), 1.42 to 42.9)]. At 3.5 years, boys showed inverse associations between maternal DLC concentrations and cord blood IgE [partial regression coefficient; -0.87 (95% CI), -1.68 to -0.06], and frequency of wheezing [OR; 0.03 (95% CI), 0.00 to 0.94] but girls did not. Discussion: As one reason for the significant association observed at 7 but absent at 3.5 years, we suggest that allergic symptoms are more obvious in older children due to matured immune function. Conclusion: The findings suggest that prenatal exposure to DLCs may modify offspring immune responses and result in increased risk of allergy among children of school age.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/76441
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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