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Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/76469

Title: Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase
Authors: Ye, Ying Browse this author
Ozaki, Taro Browse this author →KAKEN DB
Umemura, Myco Browse this author →KAKEN DB
Liu, Chengwei Browse this author →KAKEN DB
Minami, Atsushi Browse this author →KAKEN DB
Oikawa, Hideaki Browse this author →KAKEN DB
Issue Date: 7-Jan-2019
Publisher: Royal Society of Chemistry
Journal Title: Organic & biomolecular chemistry
Volume: 17
Issue: 1
Start Page: 39
End Page: 43
Publisher DOI: 10.1039/c8ob02824a
Abstract: Asperipin-2a is a ribosomally synthesized and post-translationally modified peptide isolated from Asperigillus flavus. Herein, we report the heterologous production of asperipin-2a and determination of its absolute structure. Notably, the characteristic bicyclic structure was likely constructed by a single oxidase containing the DUF3328 domain.
Type: article (author version)
URI: http://hdl.handle.net/2115/76469
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 及川 英秋

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