Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/76469

Title:	Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase
Authors:	Ye, Ying Browse this author
	Ozaki, Taro Browse this author →KAKEN DB
	Umemura, Myco Browse this author →KAKEN DB
	Liu, Chengwei Browse this author →KAKEN DB
	Minami, Atsushi Browse this author →KAKEN DB
	Oikawa, Hideaki Browse this author →KAKEN DB
Issue Date:	7-Jan-2019
Publisher:	Royal Society of Chemistry
Journal Title:	Organic & biomolecular chemistry
Volume:	17
Issue:	1
Start Page:	39
End Page:	43
Publisher DOI:	10.1039/c8ob02824a
Abstract:	Asperipin-2a is a ribosomally synthesized and post-translationally modified peptide isolated from Asperigillus flavus. Herein, we report the heterologous production of asperipin-2a and determination of its absolute structure. Notably, the characteristic bicyclic structure was likely constructed by a single oxidase containing the DUF3328 domain.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/76469
Appears in Collections:	理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 及川英秋

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