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Blonanserin suppresses impulsive action in rats

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Title: Blonanserin suppresses impulsive action in rats
Authors: Nishitani, Naoya Browse this author
Sasamori, Hitomi Browse this author
Ohmura, Yu Browse this author →KAKEN DB
Yoshida, Takayuki Browse this author →KAKEN DB
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Keywords: Impulsive behavior
Issue Date: Nov-2019
Publisher: Japanese Pharmacological Society
Journal Title: Journal of pharmacological sciences
Volume: 141
Issue: 3
Start Page: 127
End Page: 130
Publisher DOI: 10.1016/j.jphs.2019.09.013
Abstract: High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs. (C) 2019 The Authors. Production and hosting by Elsevier B.V.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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