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Blonanserin suppresses impulsive action in rats
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| Title: | Blonanserin suppresses impulsive action in rats |
| Authors: | Nishitani, Naoya Browse this author | | Sasamori, Hitomi Browse this author | | Ohmura, Yu Browse this author →KAKEN DB | | Yoshida, Takayuki Browse this author →KAKEN DB | | Yoshioka, Mitsuhiro Browse this author →KAKEN DB |
| Keywords: | Impulsive behavior | | 1-PP | | Antipsychotics |
| Issue Date: | Nov-2019 |
| Publisher: | Japanese Pharmacological Society |
| Journal Title: | Journal of pharmacological sciences |
| Volume: | 141 |
| Issue: | 3 |
| Start Page: | 127 |
| End Page: | 130 |
| Publisher DOI: | 10.1016/j.jphs.2019.09.013 |
| Abstract: | High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs. (C) 2019 The Authors. Production and hosting by Elsevier B.V. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76506 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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