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Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers : The Hokkaido study on Environment and Children's Health

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Title: Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers : The Hokkaido study on Environment and Children's Health
Authors: Minatoya, Machiko Browse this author
Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Ait Bamai, Yu Browse this author
Itoh, Sachiko Browse this author →KAKEN DB
Yamamoto, Jun Browse this author
Onoda, Yu Browse this author
Ogasawara, Kazuki Browse this author
Matsumura, Toru Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Bisphenol A
Metabolic related biomarkers
Birth cohort
Prenatal exposure
Issue Date: Feb-2018
Publisher: Elsevier
Journal Title: Environmental research
Volume: 161
Start Page: 505
End Page: 511
Publisher DOI: 10.1016/j.envres.2017.11.052
Abstract: Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Thus, this study aimed to assess the association between prenatal exposure to bisphenol A and phthalates, and cord blood metabolic-related biomarkers. Maternal serum was used during the first trimester, to determine prenatal exposure to bisphenol A and phthalates. Levels of metabolic-related biomarkers in the cord blood were also determined. Linear regression models were applied to the 365 participants with both, exposure and biomarker assessments, adjusted for maternal age, pre-pregnancy body mass index, parity, education, and sex of the child. The level of bisphenol A was negatively associated with the leptin level (β = -0.06, 95% confidence interval [CI]: -0.11, -0.01), but was positively associated with the high-molecular-weight adiponectin level, with marginal significance (β = 0.03, 95%CI: 0.00, 0.06). The mono-isobutyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), mono-(2-ethylhexyl) phthalate (MEHP), and summation of MEHP and MECPP to represent DEHP exposure (∑DEHPm) levels were inversely associated with the leptin levels (β=-0.14, 95%CI: -0.27, -0.01; β = -0.12, 95%CI: -0.24, 0.00 with marginal significance; β=0.08, 95%CI: -0.14, -0.03; and β = -0.09, 95%CI: -0.16, -0.03, respectively). The present study provided some evidence that prenatal exposure to bisphenol A and certain phthalates may modify fetal adiponectin and leptin levels.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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