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Paclitaxel-associated Acute Pain Syndrome Similarly Occurs in the Patients with or without Previously Administered Non-steroidal Anti-inflammatory Drugs Prior to Paclitaxel Administration

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Title: Paclitaxel-associated Acute Pain Syndrome Similarly Occurs in the Patients with or without Previously Administered Non-steroidal Anti-inflammatory Drugs Prior to Paclitaxel Administration
Authors: Saito, Yoshitaka Browse this author
Yamada, Takehiro Browse this author
Kobayashi, Masaki Browse this author →KAKEN DB
Sakakibara-Konishi, Jun Browse this author
Shinagawa, Naofumi Browse this author
Kinoshita, Ichiro Browse this author
Dosaka-Akita, Hirotoshi Browse this author
Iseki, Ken Browse this author →KAKEN DB
Keywords: paclitaxel
paclitaxel-associated acute pain syndrome
pain
non-steroidal anti-inflammatory drugs
arthralgia
myalgia
Issue Date: Dec-2019
Publisher: The Pharmaceutical Society of Japan (日本薬学会)
Journal Title: 薬学雑誌 Yakugaku zasshi(Journal of the pharmaceutical society of Japan)
Volume: 139
Issue: 12
Start Page: 1601
End Page: 1608
Publisher DOI: 10.1248/yakushi.19-00148
Abstract: Paclitaxel (PTX)-associated acute pain syndrome (P-APS) is characterized by disabling but transient arthralgia and myalgia in up to 80% of patients administered with PTX. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely administered to patients with cancer who have pain or fever, and are mainly used to manage P-APS. In this study, we investigated how P-APS appear in the patients who were administered NSAIDs prior to PTX injection. The incidence or severity and duration of P-APS in patients previously administered NSAIDs were compared to those of patients who were not administered NSAIDs. The relationship between previously administered NSAIDs and rescue administration for the relief of P-APS was also evaluated. It was revealed that the incidence and duration of P-APS were 72% and 4.67 +/- 2.30 d, respectively, in the control group and 84% and 6.19 +/- 3.30 d, respectively, in the NSAIDs group. There was no significant difference in the incidence and duration and the severity of P-APS between the two groups. Patients who were previously administered NSAIDs tended to obtain less pain relief from NSAIDs administered as rescue medications, and needed other medication. Univariate and multivariate analysis revealed no correlation between previously administered NSAIDs or patient characteristics and the incidence of P-APS. In this study, it was found that clinical condition that needs NSAIDs and previously administered NSAIDs prior to PTX injection do not affect the incidence, severity, and duration of P-APS. These results will help in educating patients about their medications and will contribute to the management of P-APS.
Rights: Copyright 2019 The Pharmaceutical Society of Japan
Type: article
URI: http://hdl.handle.net/2115/76725
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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