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Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months
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| Title: | Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months |
| Authors: | Ikeno, Tamiko Browse this author →KAKEN DB | | Miyashita, Chihiro Browse this author →KAKEN DB | | Nakajima, Sonomi Browse this author | | Kobayashi, Sumitaka Browse this author →KAKEN DB | | Yamazaki, Keiko Browse this author | | Saijo, Yasuaki Browse this author →KAKEN DB | | Kita, Toshiko Browse this author →KAKEN DB | | Sasaki, Seiko Browse this author →KAKEN DB | | Konishi, Kanae Browse this author | | Kajiwara, Junboku Browse this author | | Hori, Tsuguhide Browse this author | | Kishi, Reiko Browse this author →KAKEN DB |
| Keywords: | Birth-cohort study | | Dioxin-like compounds | | Prenatal exposure | | Cognitive development | | Kaufman Assessment of Battery for Children |
| Issue Date: | 15-Mar-2018 |
| Publisher: | Elsevier |
| Journal Title: | Science of the total environment |
| Volume: | 618 |
| Start Page: | 1423 |
| End Page: | 1430 |
| Publisher DOI: | 10.1016/j.scitotenv.2017.09.267 |
| Abstract: | Background: Prenatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs) or polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dioxin-like compounds [DLCs]) through environmental chemicals may affect the neurodevelopment of children. In our previous study, an inverse association was observed between prenatal DLCs and neurodevelopment of infants aged 6 months in both sexes. However, studies are yet to determine how long these adverse effects last. Objective: To examine whether the effects of DLCs on cognitive development remains at 42 months. Methods: In this prospective cohort study conducted in Sapporo, Japan, pregnant mothers' blood was analyzed for the congener level of DLCs. The Kaufman Assessment of Battery for Children (K-ABC) was used to test their children's cognitive development at 42 months. A total of 141 mother-child pairs were included in the final analysis. The multiple linear regression analysis was used to examine the association between the K-ABC scores and DLC levels in the maternal blood. Results: Seven isomers (1,2,3,6,7,8-HxCDD, 2,3,4,7,8-PeCDF, 33'44'55'-HxCB(#169), 2344'5-PenCB(#114), 233'44'5-HexCB(#156), 233'44'5'-HexCB(#157), 23'44'55'-HexCB(#167), total PCDF, and TEQ-PCDD, PCDF, PCDD/DFs levels were positively associated with the achievement score (AS) of K-ABC. However, total non-ortho PCBs were negatively associated with the Mental Processing Composite Score (MPCS) of K-ABC in males. In females, increased TEQ-dl PCB and TEQ-PCDD/F/dl-PCB were also associated with increasing AS score. Conclusions: This study suggests that the negative effects of prenatal DLC exposure on children's cognitive development at 6 months were not observed in children aged 42 months. Regarding the sex-specific effects, AS and DLCs were positively correlated in females, whereas those of MPCS and DLCs were significantly negative in males. |
| Rights: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/76951 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岸 玲子
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