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Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months

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Title: Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months
Authors: Ikeno, Tamiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Nakajima, Sonomi Browse this author
Kobayashi, Sumitaka Browse this author →KAKEN DB
Yamazaki, Keiko Browse this author
Saijo, Yasuaki Browse this author →KAKEN DB
Kita, Toshiko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Konishi, Kanae Browse this author
Kajiwara, Junboku Browse this author
Hori, Tsuguhide Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Birth-cohort study
Dioxin-like compounds
Prenatal exposure
Cognitive development
Kaufman Assessment of Battery for Children
Issue Date: 15-Mar-2018
Publisher: Elsevier
Journal Title: Science of the total environment
Volume: 618
Start Page: 1423
End Page: 1430
Publisher DOI: 10.1016/j.scitotenv.2017.09.267
Abstract: Background: Prenatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs) or polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dioxin-like compounds [DLCs]) through environmental chemicals may affect the neurodevelopment of children. In our previous study, an inverse association was observed between prenatal DLCs and neurodevelopment of infants aged 6 months in both sexes. However, studies are yet to determine how long these adverse effects last. Objective: To examine whether the effects of DLCs on cognitive development remains at 42 months. Methods: In this prospective cohort study conducted in Sapporo, Japan, pregnant mothers' blood was analyzed for the congener level of DLCs. The Kaufman Assessment of Battery for Children (K-ABC) was used to test their children's cognitive development at 42 months. A total of 141 mother-child pairs were included in the final analysis. The multiple linear regression analysis was used to examine the association between the K-ABC scores and DLC levels in the maternal blood. Results: Seven isomers (1,2,3,6,7,8-HxCDD, 2,3,4,7,8-PeCDF, 33'44'55'-HxCB(#169), 2344'5-PenCB(#114), 233'44'5-HexCB(#156), 233'44'5'-HexCB(#157), 23'44'55'-HexCB(#167), total PCDF, and TEQ-PCDD, PCDF, PCDD/DFs levels were positively associated with the achievement score (AS) of K-ABC. However, total non-ortho PCBs were negatively associated with the Mental Processing Composite Score (MPCS) of K-ABC in males. In females, increased TEQ-dl PCB and TEQ-PCDD/F/dl-PCB were also associated with increasing AS score. Conclusions: This study suggests that the negative effects of prenatal DLC exposure on children's cognitive development at 6 months were not observed in children aged 42 months. Regarding the sex-specific effects, AS and DLCs were positively correlated in females, whereas those of MPCS and DLCs were significantly negative in males.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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