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Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp.

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Title: Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp.
Authors: Gao, Lei Browse this author
Narita, Koji Browse this author
Ozaki, Taro Browse this author
Kumakura, Naoyoshi Browse this author
Gan, Pamela Browse this author
Minami, Atsushi Browse this author →KAKEN DB
Liu, Chengwei Browse this author
Lei, Xiaoguang Browse this author
Shirasu, Ken Browse this author
Oikawa, Hideaki Browse this author →KAKEN DB
Keywords: Sesterterpene synthase
Genome mining
Natural product biosynthesis
Heterologous expression
Issue Date: 21-Mar-2018
Publisher: Elsevier
Journal Title: Tetrahedron Letters
Volume: 59
Issue: 12
Start Page: 1136
End Page: 1139
Publisher DOI: 10.1016/j.tetlet.2018.02.022
Abstract: Two homologous gene clusters for the biosynthesis of sesterterpenes betaestacins were identified from two phytopathogens, Phoma betae and Colletotrichum orbiculare. Heterologous expression of identified oxidation enzymes with previously-characterized PbTS1 (BtcA(pb)) resulted in the production of seven novel sesterterpenes. Although both strains possessed homologous enzymes, oxidation state of corresponding products were different from each other, suggesting that structural diversification of sesterterpene skeletons might be achieved by these homologous enzymes with different functions. (C) 2013 Elsevier Ltd. All rights reserved.
Rights: ©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 及川 英秋

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