HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

Palladium-Catalyzed Decarboxylative Alkynylation of alpha-Acyloxyketones by C(sp(3))-O Bond Cleavage

Files in This Item:
WoS_89426_Doi.pdf505.88 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Palladium-Catalyzed Decarboxylative Alkynylation of alpha-Acyloxyketones by C(sp(3))-O Bond Cleavage
Authors: Doi, Ryohei Browse this author
Yabuta, Akimasa Browse this author
Sato, Yoshihiro Browse this author →KAKEN DB
Keywords: alkynylation
Issue Date: 23-Apr-2019
Publisher: Wiley-Blackwell
Journal Title: Chemistry-A European journal
Volume: 25
Issue: 23
Start Page: 5884
End Page: 5888
Publisher DOI: 10.1002/chem.201900582
Abstract: Palladium-catalyzed decarboxylative alkynylation of alpha-acyloxyketones triggered by C(sp(3))-O bond cleavage is disclosed. The decarboxylation strategy featuring a neutral reaction condition enabled an unprecedent catalytic alkynylation of a ketone enolate. The reaction was applied to a variety of substrates, giving desired products in good yields. We successfully obtained X-ray crystallography of a new palladium-enolate intermediate that was synthesized by a reaction of [Pd(cod)(CH2TMS)(2)] with XPhos and alpha-acyloxyketone at room temperature, indicating facile C(sp(3))-O bond disconnection.
Rights: This is the peer-reviewed version of the following article:, which has been published in final form at 10.1002/chem.201900582. This article may be used for non-commercial purposes in accordance with Wiley-VCH Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 土井 良平

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University