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Corticobasal ganglia projecting neurons are required for juvenile vocal learning but not for adult vocal plasticity in songbirds

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Title: Corticobasal ganglia projecting neurons are required for juvenile vocal learning but not for adult vocal plasticity in songbirds
Authors: Sanchez-Valpuesta, Miguel Browse this author
Suzuki, Yumeno Browse this author
Shibata, Yukino Browse this author
Toji, Noriyuki Browse this author
Ji, Yu Browse this author
Afrin, Nasiba Browse this author
Asogwa, Chinweike Norman Browse this author
Kojima, Ippei Browse this author
Mizuguchi, Daisuke Browse this author
Kojima, Satoshi Browse this author
Okanoya, Kazuo Browse this author
Okado, Haruo Browse this author
Kobayashi, Kenta Browse this author
Wada, Kazuhiro Browse this author →KAKEN DB
Keywords: critical period
sensorimotor learning
time-locked firing
zebra finch
sensory feedback
Issue Date: 5-Nov-2019
Publisher: National Academy of Sciences.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Volume: 116
Issue: 45
Start Page: 22833
End Page: 22843
Publisher DOI: 10.1073/pnas.1913575116
Abstract: Birdsong, like human speech, consists of a sequence of temporally precise movements acquired through vocal learning. The learning of such sequential vocalizations depends on the neural function of the motor cortex and basal ganglia. However, it is unknown how the connections between cortical and basal ganglia components contribute to vocal motor skill learning, as mammalian motor cortices serve multiple types of motor action and most experimentally tractable animals do not exhibit vocal learning. Here, we leveraged the zebra finch, a songbird, as an animal model to explore the function of the connectivity between cortex-like (HVC) and basal ganglia (area X), connected by HVC(x) projection neurons with temporally precise firing during singing. By specifically ablating HVC(x) neurons, juvenile zebra finches failed to copy tutored syllable acoustics and developed temporally unstable songs with less sequence consistency. In contrast, HVC(x) -ablated adults did not alter their learned song structure, but generated acoustic fluctuations and responded to auditory feedback disruption by the introduction of song deterioration, as did normal adults. These results indicate that the corticobasal ganglia input is important for learning the acoustic and temporal aspects of song structure, but not for generating vocal fluctuations that contribute to the maintenance of an already learned vocal pattern.
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 和多 和宏

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