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A Simple Method for the Preparation of Stainless and Highly Pure Trichloroacetimidates

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Title: A Simple Method for the Preparation of Stainless and Highly Pure Trichloroacetimidates
Authors: Ikeuchi, Kazutada Browse this author
Murasawa, Kentaro Browse this author
Yamada, Hidetoshi Browse this author
Keywords: preparation
solvent optimization
visual detection
Issue Date: Jul-2019
Publisher: Georg Thieme Verlag
Journal Title: Synlett
Volume: 30
Issue: 11
Start Page: 1308
End Page: 1312
Publisher DOI: 10.1055/s-0037-1611551
Abstract: We describe a method for obtaining various allylic, benzylic, and glucosyl 2,2,2-trichloroacetimidates (TCAIs) as stainless liquids or solids at the crude stage. The general synthetic method for the preparation of TCAIs often leads to stained products, and further purification of crude TCAIs causes decomposition due to their instability. In the described method, we use a solvent that barely dissolves the reactant, providing stainless and sufficiently pure TCAIs without requiring a purification step. Furthermore, the reaction mixture is turbid at the beginning and clear at the end, allowing us to monitor the progress of the reaction visually.
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 池内 和忠

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