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Lipid polarity gradient formed by omega-hydroxy lipids in tear film prevents dry eye disease

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Title: Lipid polarity gradient formed by omega-hydroxy lipids in tear film prevents dry eye disease
Authors: Miyamoto, Masatoshi Browse this author
Sassa, Takayuki Browse this author →KAKEN DB
Sawai, Megumi Browse this author
Kihara, Akio Browse this author →KAKEN DB
Issue Date: 7-Apr-2020
Publisher: eLife Sciences Publications
Journal Title: Elife
Volume: 9
Start Page: e53582
Publisher DOI: 10.7554/eLife.53582
Abstract: Meibum lipids form a lipid layer on the outermost side of the tear film and function to prevent water evaporation and reduce surface tension. (O-Acyl)-omega-hydroxy fatty acids (OAHFAs), a subclass of these lipids, are thought to be involved in connecting the lipid and aqueous layers in tears, although their actual function and synthesis pathway have to date remained unclear. Here, we reveal that the fatty acid omega-hydroxylase Cyp4f39 is involved in OAHFA production. Cyp4f39-deficient mice exhibited damaged corneal epithelium and shortening of tear film break-up time, both indicative of dry eye disease. In addition, tears accumulated on the lower eyelid side, indicating increased tear surface tension. In Cyp4f39-deficient mice, the production of wax diesters (type 1 omega and 2 omega) and cholesteryl OAHFAs was also impaired. These OAHFA derivatives show intermediate polarity among meibum lipids, suggesting that OAHFAs and their derivatives contribute to lipid polarity gradient formation for tear film stabilization.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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