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Involvement of Peptide Epimerization in Poly-gamma-glutamic Acid Biosynthesis

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Title: Involvement of Peptide Epimerization in Poly-gamma-glutamic Acid Biosynthesis
Authors: Ogasawara, Yasushi Browse this author →KAKEN DB
Shigematsu, Mayuko Browse this author
Sato, Shota Browse this author
Kato, Hinata Browse this author
Dairi, Tohru Browse this author →KAKEN DB
Issue Date: 7-Jun-2019
Publisher: American Chemical Society
Journal Title: Organic letters
Volume: 21
Issue: 11
Start Page: 3972
End Page: 3975
Publisher DOI: 10.1021/acs.orglett.9b01121
Abstract: Poly-gamma-glutamic acid (PGA) is a promising polymer that comprises D- and L-glutamic acid (Glu) connected via an amide bond. PGA is biosynthesized by a transmembrane enzyme complex composed of PgsB, PgsC, and PgsA. However, the detailed reaction, especially the mechanism for introducing D-Glu residues into PGA, remains elusive. We herein report isotope tracer experiments with deuterated L- and D-Glu and demonstrate that epimerization of a growing peptide is involved in PGA biosynthesis.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小笠原 泰志

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