Synthesis of 2-alkyl-2-boryl-substituted-tetrahydrofurans via copper(i)-catalysed borylative cyclization of aliphatic ketones


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/78636

Title:	Synthesis of 2-alkyl-2-boryl-substituted-tetrahydrofurans via copper(i)-catalysed borylative cyclization of aliphatic ketones
Authors:	Kubota, Koji Browse this author
	Uesugi, Minami Browse this author
	Osaki, Shun Browse this author
	Ito, Hajime Browse this author →KAKEN DB
Issue Date:	21-Jun-2019
Publisher:	Royal Society of Chemistry
Journal Title:	Organic & biomolecular chemistry
Volume:	17
Issue:	23
Start Page:	5680
End Page:	5683
Publisher DOI:	10.1039/c9ob00962k
Abstract:	A new method was developed for synthesizing 2-alkyl-2-boryl-tetrahydrofuran derivatives from aliphatic ketones using a copper(i)/N-heterocyclic carbene complex catalyst. This reaction presumably proceeds through the nucleophilic addition of a borylcopper(i) intermediate to ketone, followed by intramolecular substitution of the resulting alkoxide for the halide leaving group. The new borylation products, 2-alkyl-2-boryl-tetrahydrofuran derivatives with a condensed structure around the C-B bond, cannot be synthesized by other methods.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/78636
Appears in Collections:	工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久保田浩司

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