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In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid.

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Title: In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid.
Authors: Sato, Yuki Browse this author →KAKEN DB
Itagaki, Shirou Browse this author
Kurokawa, Toshimitsu Browse this author
Ogura, Jiro Browse this author
Kobayashi, Masaki Browse this author →KAKEN DB
Hirano, Takeshi Browse this author
Sugawara, Mitsuru Browse this author →KAKEN DB
Iseki, Ken Browse this author →KAKEN DB
Keywords: intestine
antioxidant
chlorogenic acid
caffeic acid
absorption
ischemia-reperfusion
Issue Date: 17-Jan-2011
Journal Title: International journal of pharmaceutics
Volume: 403
Issue: 1-2
Start Page: 136
End Page: 138
Publisher DOI: 10.1016/j.ijpharm.2010.09.035
PMID: 20933071
Abstract: Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid. Although these polyphenols have received much attention, there is little evidence indicating a relationship between the effect and the rate of absorption. In this study, we focused on the beneficial effects of chlorogenic acid and caffeic acid, a major metabolite of chlorogenic acid. We carried out in vitro and in vivo experiments. In the in vitro study, caffeic acid had stronger antioxidant activity than that of chlorogenic acid. The uptake of chlorogenic acid by Caco-2 cells was much less than that of caffeic acid. The physiological importance of an orally administered compound depends on its availability for intestinal absorption and subsequent interaction with target tissues. We then used an intestinal ischemia-reperfusion model to evaluate antioxidant activities in vivo. We found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury. Since caffeic acid has a stronger antioxidant activity than that of chlorogenic acid and chlorogenic acid is hydrolyzed into caffeic acid in the intestine, it is possible that caffeic acid plays a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury.
Rights: ©2011, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/78780
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 夕紀

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